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Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study
Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum stud...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474267/ https://www.ncbi.nlm.nih.gov/pubmed/28660215 http://dx.doi.org/10.1155/2017/5619402 |
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author | Süsal, Caner Fichtner, Alexander Tönshoff, Burkhard Mehrabi, Arianeb Zeier, Martin Morath, Christian |
author_facet | Süsal, Caner Fichtner, Alexander Tönshoff, Burkhard Mehrabi, Arianeb Zeier, Martin Morath, Christian |
author_sort | Süsal, Caner |
collection | PubMed |
description | Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of transplantations could be increased in high-risk presensitized patients and the previously existing impact of antibodies on graft survival could greatly be diminished but not totally eliminated. More recent findings led to the hypothesis that T cell help from a preactivated immune system supports the harmful effects of pretransplant donor-specific HLA antibodies that otherwise disappear in many cases after transplantation without any consequence. |
format | Online Article Text |
id | pubmed-5474267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54742672017-06-28 Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study Süsal, Caner Fichtner, Alexander Tönshoff, Burkhard Mehrabi, Arianeb Zeier, Martin Morath, Christian J Immunol Res Review Article Herein, we summarize our recent findings from the international Collaborative Transplant Study (CTS) and Heidelberg Transplant Center regarding the role of HLA antibodies in kidney transplantation and their application into the clinical routine. Based on the antibody findings from the CTS serum study, an algorithm was developed in 2006 for the transplantation of high-risk sensitized patients at the Heidelberg Transplant Center which includes seven different pre- and posttransplant measures. Using this algorithm, the number of transplantations could be increased in high-risk presensitized patients and the previously existing impact of antibodies on graft survival could greatly be diminished but not totally eliminated. More recent findings led to the hypothesis that T cell help from a preactivated immune system supports the harmful effects of pretransplant donor-specific HLA antibodies that otherwise disappear in many cases after transplantation without any consequence. Hindawi 2017 2017-06-04 /pmc/articles/PMC5474267/ /pubmed/28660215 http://dx.doi.org/10.1155/2017/5619402 Text en Copyright © 2017 Caner Süsal et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Süsal, Caner Fichtner, Alexander Tönshoff, Burkhard Mehrabi, Arianeb Zeier, Martin Morath, Christian Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title | Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title_full | Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title_fullStr | Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title_full_unstemmed | Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title_short | Clinical Relevance of HLA Antibodies in Kidney Transplantation: Recent Data from the Heidelberg Transplant Center and the Collaborative Transplant Study |
title_sort | clinical relevance of hla antibodies in kidney transplantation: recent data from the heidelberg transplant center and the collaborative transplant study |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474267/ https://www.ncbi.nlm.nih.gov/pubmed/28660215 http://dx.doi.org/10.1155/2017/5619402 |
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