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Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats

OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eig...

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Autores principales: Guzel, Nizamettin, Sayit, Emrah, Aynaci, Osman, Kerimoglu, Servet, Yulug, Esin, Topbas, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ATHA EDITORA 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474412/
https://www.ncbi.nlm.nih.gov/pubmed/28642670
http://dx.doi.org/10.1590/1413-785220172503156966
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author Guzel, Nizamettin
Sayit, Emrah
Aynaci, Osman
Kerimoglu, Servet
Yulug, Esin
Topbas, Murat
author_facet Guzel, Nizamettin
Sayit, Emrah
Aynaci, Osman
Kerimoglu, Servet
Yulug, Esin
Topbas, Murat
author_sort Guzel, Nizamettin
collection PubMed
description OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire. The G. biloba groups received 60 mg/kg oral G. biloba extract once daily. No medication was given to the control groups. On days 7, 21 and 35, both sets of femurs were evaluated radiologically and histopathologically. RESULTS: Histological evaluation revealed that the G. biloba groups had significant differences at 21 and 35 days (p<0.05). The G. biloba group showed a significant difference in terms of bone formation on day 21 when compared to the control group (p<0.05). CONCLUSIONS: This study indicated that the use of G. biloba extract accelerated fracture healing. Both radiological and histological differences were detected, but the histological differences were more remarkable. Level of Evidence I, High Quality Randomized Trial.
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spelling pubmed-54744122017-06-22 Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats Guzel, Nizamettin Sayit, Emrah Aynaci, Osman Kerimoglu, Servet Yulug, Esin Topbas, Murat Acta Ortop Bras Original Article OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire. The G. biloba groups received 60 mg/kg oral G. biloba extract once daily. No medication was given to the control groups. On days 7, 21 and 35, both sets of femurs were evaluated radiologically and histopathologically. RESULTS: Histological evaluation revealed that the G. biloba groups had significant differences at 21 and 35 days (p<0.05). The G. biloba group showed a significant difference in terms of bone formation on day 21 when compared to the control group (p<0.05). CONCLUSIONS: This study indicated that the use of G. biloba extract accelerated fracture healing. Both radiological and histological differences were detected, but the histological differences were more remarkable. Level of Evidence I, High Quality Randomized Trial. ATHA EDITORA 2017 /pmc/articles/PMC5474412/ /pubmed/28642670 http://dx.doi.org/10.1590/1413-785220172503156966 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Guzel, Nizamettin
Sayit, Emrah
Aynaci, Osman
Kerimoglu, Servet
Yulug, Esin
Topbas, Murat
Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title_full Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title_fullStr Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title_full_unstemmed Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title_short Ginkgo Biloba improves bone formation during fracture healing: an experimental study in rats
title_sort ginkgo biloba improves bone formation during fracture healing: an experimental study in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474412/
https://www.ncbi.nlm.nih.gov/pubmed/28642670
http://dx.doi.org/10.1590/1413-785220172503156966
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