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Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner
The IL-17-producing CD4(+) T helper cell (Th17) differentiation is affected by stimulation of the aryl hydrocarbon receptor (AhR) pathway and by hypoxia-inducible factor 1 alpha (HIF-1α). In some cases, Th17 become non-pathogenic and produce IL-10. However, the initiating events triggering this phen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474482/ https://www.ncbi.nlm.nih.gov/pubmed/28674533 http://dx.doi.org/10.3389/fimmu.2017.00698 |