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Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis

OBJECTIVES: To determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterati...

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Autores principales: Terada, Tatsuhiro, Miyata, Jun, Obi, Tomokazu, Kubota, Manabu, Yoshizumi, Miho, Yamazaki, Kinya, Mizoguchi, Kouichi, Murai, Toshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474710/
https://www.ncbi.nlm.nih.gov/pubmed/28638712
http://dx.doi.org/10.1002/brb3.707
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author Terada, Tatsuhiro
Miyata, Jun
Obi, Tomokazu
Kubota, Manabu
Yoshizumi, Miho
Yamazaki, Kinya
Mizoguchi, Kouichi
Murai, Toshiya
author_facet Terada, Tatsuhiro
Miyata, Jun
Obi, Tomokazu
Kubota, Manabu
Yoshizumi, Miho
Yamazaki, Kinya
Mizoguchi, Kouichi
Murai, Toshiya
author_sort Terada, Tatsuhiro
collection PubMed
description OBJECTIVES: To determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterations related to cognitive impairments occur in relatively mild stage of ALS. MATERIALS AND METHODS: Twenty‐four ALS patients with a Mini‐Mental State Examination score of >23, a normal score on the Self‐Rating Depression Scale, little or no disturbance in speech and handling utensils on the ALS Functional Rating Scale (ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial blood gas analysis), and two age‐matched normal control groups (one for FAB assessment and the other for brain morphometry) underwent FAB testing and structural magnetic resonance imaging. We applied voxel‐based morphometry to investigate the relationship between the FAB score and regional brain alteration, and assessed the relationship between the altered regional brain volume and ALSFRS or respiratory tests. RESULTS: Frontal assessment battery scores were significantly lower in ALS patients than in normal controls. Volume reduction in the right orbitofrontal gyrus in ALS was correlated with a lower FAB score. There was no correlation between the right orbitofrontal gyrus volume and ALSFRS or respiratory tests. CONCLUSIONS: The results suggest that the FAB is an adequate tool for detecting cognitive impairments related to frontal lobe pathology in the relatively mild stage of ALS, independent of physical dysfunctions.
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spelling pubmed-54747102017-06-21 Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis Terada, Tatsuhiro Miyata, Jun Obi, Tomokazu Kubota, Manabu Yoshizumi, Miho Yamazaki, Kinya Mizoguchi, Kouichi Murai, Toshiya Brain Behav Original Research OBJECTIVES: To determine the potential utility of the frontal assessment battery (FAB) in assessing cognitive impairments in amyotrophic lateral sclerosis (ALS), we investigated the association between the FAB score and regional gray matter volume, and ascertained whether the regional brain alterations related to cognitive impairments occur in relatively mild stage of ALS. MATERIALS AND METHODS: Twenty‐four ALS patients with a Mini‐Mental State Examination score of >23, a normal score on the Self‐Rating Depression Scale, little or no disturbance in speech and handling utensils on the ALS Functional Rating Scale (ALSFRS), and normal measures on respiratory tests (respiratory function test and arterial blood gas analysis), and two age‐matched normal control groups (one for FAB assessment and the other for brain morphometry) underwent FAB testing and structural magnetic resonance imaging. We applied voxel‐based morphometry to investigate the relationship between the FAB score and regional brain alteration, and assessed the relationship between the altered regional brain volume and ALSFRS or respiratory tests. RESULTS: Frontal assessment battery scores were significantly lower in ALS patients than in normal controls. Volume reduction in the right orbitofrontal gyrus in ALS was correlated with a lower FAB score. There was no correlation between the right orbitofrontal gyrus volume and ALSFRS or respiratory tests. CONCLUSIONS: The results suggest that the FAB is an adequate tool for detecting cognitive impairments related to frontal lobe pathology in the relatively mild stage of ALS, independent of physical dysfunctions. John Wiley and Sons Inc. 2017-04-12 /pmc/articles/PMC5474710/ /pubmed/28638712 http://dx.doi.org/10.1002/brb3.707 Text en © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Terada, Tatsuhiro
Miyata, Jun
Obi, Tomokazu
Kubota, Manabu
Yoshizumi, Miho
Yamazaki, Kinya
Mizoguchi, Kouichi
Murai, Toshiya
Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title_full Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title_fullStr Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title_full_unstemmed Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title_short Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
title_sort frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474710/
https://www.ncbi.nlm.nih.gov/pubmed/28638712
http://dx.doi.org/10.1002/brb3.707
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