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Risk factors and outcomes associated with alcohol relapse after liver transplantation
Alcoholic liver disease (ALD) is the second most common indication for liver transplantation (LT) in the United States and Europe. Unlike other indications for LT, transplantation for ALD may be controversial due to the concern for alcohol relapse and non-compliance after LT. However, the overall su...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474723/ https://www.ncbi.nlm.nih.gov/pubmed/28660011 http://dx.doi.org/10.4254/wjh.v9.i17.771 |
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author | Lim, Jane Curry, Michael P Sundaram, Vinay |
author_facet | Lim, Jane Curry, Michael P Sundaram, Vinay |
author_sort | Lim, Jane |
collection | PubMed |
description | Alcoholic liver disease (ALD) is the second most common indication for liver transplantation (LT) in the United States and Europe. Unlike other indications for LT, transplantation for ALD may be controversial due to the concern for alcohol relapse and non-compliance after LT. However, the overall survival in patients transplanted for ALD is comparable or higher than in patients transplanted for other etiologies of liver disease. While the rate of alcohol use after liver transplantation does not differ among various etiologies of liver disease, alcohol relapse after transplantation for ALD has been associated with complications such as graft rejection, graft loss, recurrent alcoholic cirrhosis and reduced long-term patient survival. Given these potential complications, our review aimed to discuss risk factors associated with alcohol relapse and the efficacy of various interventions attempted to reduce the risk of alcohol relapse. We also describe the impact of alcohol relapse on post-transplant outcomes including graft and patient survival. Overall, alcohol liver disease remains an appropriate indication for liver transplantation, and long-term mortality in this group of patients is primarily attributed to cardiovascular disease or de novo malignancies rather than alcohol related hepatic complications, among those who relapse. |
format | Online Article Text |
id | pubmed-5474723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-54747232017-06-28 Risk factors and outcomes associated with alcohol relapse after liver transplantation Lim, Jane Curry, Michael P Sundaram, Vinay World J Hepatol Minireviews Alcoholic liver disease (ALD) is the second most common indication for liver transplantation (LT) in the United States and Europe. Unlike other indications for LT, transplantation for ALD may be controversial due to the concern for alcohol relapse and non-compliance after LT. However, the overall survival in patients transplanted for ALD is comparable or higher than in patients transplanted for other etiologies of liver disease. While the rate of alcohol use after liver transplantation does not differ among various etiologies of liver disease, alcohol relapse after transplantation for ALD has been associated with complications such as graft rejection, graft loss, recurrent alcoholic cirrhosis and reduced long-term patient survival. Given these potential complications, our review aimed to discuss risk factors associated with alcohol relapse and the efficacy of various interventions attempted to reduce the risk of alcohol relapse. We also describe the impact of alcohol relapse on post-transplant outcomes including graft and patient survival. Overall, alcohol liver disease remains an appropriate indication for liver transplantation, and long-term mortality in this group of patients is primarily attributed to cardiovascular disease or de novo malignancies rather than alcohol related hepatic complications, among those who relapse. Baishideng Publishing Group Inc 2017-06-18 2017-06-18 /pmc/articles/PMC5474723/ /pubmed/28660011 http://dx.doi.org/10.4254/wjh.v9.i17.771 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Lim, Jane Curry, Michael P Sundaram, Vinay Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title | Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title_full | Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title_fullStr | Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title_full_unstemmed | Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title_short | Risk factors and outcomes associated with alcohol relapse after liver transplantation |
title_sort | risk factors and outcomes associated with alcohol relapse after liver transplantation |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474723/ https://www.ncbi.nlm.nih.gov/pubmed/28660011 http://dx.doi.org/10.4254/wjh.v9.i17.771 |
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