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Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-w...

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Autores principales:	Nolte, Ilja M., Munoz, M. Loretto, Tragante, Vinicius, Amare, Azmeraw T., Jansen, Rick, Vaez, Ahmad, von der Heyde, Benedikt, Avery, Christy L., Bis, Joshua C., Dierckx, Bram, van Dongen, Jenny, Gogarten, Stephanie M., Goyette, Philippe, Hernesniemi, Jussi, Huikari, Ville, Hwang, Shih-Jen, Jaju, Deepali, Kerr, Kathleen F., Kluttig, Alexander, Krijthe, Bouwe P., Kumar, Jitender, van der Laan, Sander W., Lyytikäinen, Leo-Pekka, Maihofer, Adam X., Minassian, Arpi, van der Most, Peter J., Müller-Nurasyid, Martina, Nivard, Michel, Salvi, Erika, Stewart, James D., Thayer, Julian F., Verweij, Niek, Wong, Andrew, Zabaneh, Delilah, Zafarmand, Mohammad H., Abdellaoui, Abdel, Albarwani, Sulayma, Albert, Christine, Alonso, Alvaro, Ashar, Foram, Auvinen, Juha, Axelsson, Tomas, Baker, Dewleen G., de Bakker, Paul I. W., Barcella, Matteo, Bayoumi, Riad, Bieringa, Rob J., Boomsma, Dorret, Boucher, Gabrielle, Britton, Annie R., Christophersen, Ingrid, Dietrich, Andrea, Ehret, George B., Ellinor, Patrick T., Eskola, Markku, Felix, Janine F., Floras, John S., Franco, Oscar H., Friberg, Peter, Gademan, Maaike G. J., Geyer, Mark A., Giedraitis, Vilmantas, Hartman, Catharina A., Hemerich, Daiane, Hofman, Albert, Hottenga, Jouke-Jan, Huikuri, Heikki, Hutri-Kähönen, Nina, Jouven, Xavier, Junttila, Juhani, Juonala, Markus, Kiviniemi, Antti M., Kors, Jan A., Kumari, Meena, Kuznetsova, Tatiana, Laurie, Cathy C., Lefrandt, Joop D., Li, Yong, Li, Yun, Liao, Duanping, Limacher, Marian C., Lin, Henry J., Lindgren, Cecilia M., Lubitz, Steven A., Mahajan, Anubha, McKnight, Barbara, zu Schwabedissen, Henriette Meyer, Milaneschi, Yuri, Mononen, Nina, Morris, Andrew P., Nalls, Mike A., Navis, Gerjan, Neijts, Melanie, Nikus, Kjell, North, Kari E., O'Connor, Daniel T., Ormel, Johan, Perz, Siegfried, Peters, Annette, Psaty, Bruce M., Raitakari, Olli T., Risbrough, Victoria B., Sinner, Moritz F., Siscovick, David, Smit, Johannes H., Smith, Nicholas L., Soliman, Elsayed Z., Sotoodehnia, Nona, Staessen, Jan A., Stein, Phyllis K., Stilp, Adrienne M., Stolarz-Skrzypek, Katarzyna, Strauch, Konstantin, Sundström, Johan, Swenne, Cees A., Syvänen, Ann-Christine, Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thornton, Timothy A., Tinker, Lesley E., Uitterlinden, André G., van Setten, Jessica, Voss, Andreas, Waldenberger, Melanie, Wilhelmsen, Kirk C., Willemsen, Gonneke, Wong, Quenna, Zhang, Zhu-Ming, Zonderman, Alan B., Cusi, Daniele, Evans, Michele K., Greiser, Halina K., van der Harst, Pim, Hassan, Mohammad, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kääb, Stefan, Kähönen, Mika, Kivimaki, Mika, Kooperberg, Charles, Kuh, Diana, Lehtimäki, Terho, Lind, Lars, Nievergelt, Caroline M., O'Donnell, Chris J., Oldehinkel, Albertine J., Penninx, Brenda, Reiner, Alexander P., Riese, Harriëtte, van Roon, Arie M., Rioux, John D., Rotter, Jerome I., Sofer, Tamar, Stricker, Bruno H., Tiemeier, Henning, Vrijkotte, Tanja G. M., Asselbergs, Folkert W., Brundel, Bianca J. J. M., Heckbert, Susan R., Whitsel, Eric A., den Hoed, Marcel, Snieder, Harold, de Geus, Eco J. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732/ https://www.ncbi.nlm.nih.gov/pubmed/28613276 http://dx.doi.org/10.1038/ncomms15805

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author	Nolte, Ilja M. Munoz, M. Loretto Tragante, Vinicius Amare, Azmeraw T. Jansen, Rick Vaez, Ahmad von der Heyde, Benedikt Avery, Christy L. Bis, Joshua C. Dierckx, Bram van Dongen, Jenny Gogarten, Stephanie M. Goyette, Philippe Hernesniemi, Jussi Huikari, Ville Hwang, Shih-Jen Jaju, Deepali Kerr, Kathleen F. Kluttig, Alexander Krijthe, Bouwe P. Kumar, Jitender van der Laan, Sander W. Lyytikäinen, Leo-Pekka Maihofer, Adam X. Minassian, Arpi van der Most, Peter J. Müller-Nurasyid, Martina Nivard, Michel Salvi, Erika Stewart, James D. Thayer, Julian F. Verweij, Niek Wong, Andrew Zabaneh, Delilah Zafarmand, Mohammad H. Abdellaoui, Abdel Albarwani, Sulayma Albert, Christine Alonso, Alvaro Ashar, Foram Auvinen, Juha Axelsson, Tomas Baker, Dewleen G. de Bakker, Paul I. W. Barcella, Matteo Bayoumi, Riad Bieringa, Rob J. Boomsma, Dorret Boucher, Gabrielle Britton, Annie R. Christophersen, Ingrid Dietrich, Andrea Ehret, George B. Ellinor, Patrick T. Eskola, Markku Felix, Janine F. Floras, John S. Franco, Oscar H. Friberg, Peter Gademan, Maaike G. J. Geyer, Mark A. Giedraitis, Vilmantas Hartman, Catharina A. Hemerich, Daiane Hofman, Albert Hottenga, Jouke-Jan Huikuri, Heikki Hutri-Kähönen, Nina Jouven, Xavier Junttila, Juhani Juonala, Markus Kiviniemi, Antti M. Kors, Jan A. Kumari, Meena Kuznetsova, Tatiana Laurie, Cathy C. Lefrandt, Joop D. Li, Yong Li, Yun Liao, Duanping Limacher, Marian C. Lin, Henry J. Lindgren, Cecilia M. Lubitz, Steven A. Mahajan, Anubha McKnight, Barbara zu Schwabedissen, Henriette Meyer Milaneschi, Yuri Mononen, Nina Morris, Andrew P. Nalls, Mike A. Navis, Gerjan Neijts, Melanie Nikus, Kjell North, Kari E. O'Connor, Daniel T. Ormel, Johan Perz, Siegfried Peters, Annette Psaty, Bruce M. Raitakari, Olli T. Risbrough, Victoria B. Sinner, Moritz F. Siscovick, David Smit, Johannes H. Smith, Nicholas L. Soliman, Elsayed Z. Sotoodehnia, Nona Staessen, Jan A. Stein, Phyllis K. Stilp, Adrienne M. Stolarz-Skrzypek, Katarzyna Strauch, Konstantin Sundström, Johan Swenne, Cees A. Syvänen, Ann-Christine Tardif, Jean-Claude Taylor, Kent D. Teumer, Alexander Thornton, Timothy A. Tinker, Lesley E. Uitterlinden, André G. van Setten, Jessica Voss, Andreas Waldenberger, Melanie Wilhelmsen, Kirk C. Willemsen, Gonneke Wong, Quenna Zhang, Zhu-Ming Zonderman, Alan B. Cusi, Daniele Evans, Michele K. Greiser, Halina K. van der Harst, Pim Hassan, Mohammad Ingelsson, Erik Järvelin, Marjo-Riitta Kääb, Stefan Kähönen, Mika Kivimaki, Mika Kooperberg, Charles Kuh, Diana Lehtimäki, Terho Lind, Lars Nievergelt, Caroline M. O'Donnell, Chris J. Oldehinkel, Albertine J. Penninx, Brenda Reiner, Alexander P. Riese, Harriëtte van Roon, Arie M. Rioux, John D. Rotter, Jerome I. Sofer, Tamar Stricker, Bruno H. Tiemeier, Henning Vrijkotte, Tanja G. M. Asselbergs, Folkert W. Brundel, Bianca J. J. M. Heckbert, Susan R. Whitsel, Eric A. den Hoed, Marcel Snieder, Harold de Geus, Eco J. C.
author_facet	Nolte, Ilja M. Munoz, M. Loretto Tragante, Vinicius Amare, Azmeraw T. Jansen, Rick Vaez, Ahmad von der Heyde, Benedikt Avery, Christy L. Bis, Joshua C. Dierckx, Bram van Dongen, Jenny Gogarten, Stephanie M. Goyette, Philippe Hernesniemi, Jussi Huikari, Ville Hwang, Shih-Jen Jaju, Deepali Kerr, Kathleen F. Kluttig, Alexander Krijthe, Bouwe P. Kumar, Jitender van der Laan, Sander W. Lyytikäinen, Leo-Pekka Maihofer, Adam X. Minassian, Arpi van der Most, Peter J. Müller-Nurasyid, Martina Nivard, Michel Salvi, Erika Stewart, James D. Thayer, Julian F. Verweij, Niek Wong, Andrew Zabaneh, Delilah Zafarmand, Mohammad H. Abdellaoui, Abdel Albarwani, Sulayma Albert, Christine Alonso, Alvaro Ashar, Foram Auvinen, Juha Axelsson, Tomas Baker, Dewleen G. de Bakker, Paul I. W. Barcella, Matteo Bayoumi, Riad Bieringa, Rob J. Boomsma, Dorret Boucher, Gabrielle Britton, Annie R. Christophersen, Ingrid Dietrich, Andrea Ehret, George B. Ellinor, Patrick T. Eskola, Markku Felix, Janine F. Floras, John S. Franco, Oscar H. Friberg, Peter Gademan, Maaike G. J. Geyer, Mark A. Giedraitis, Vilmantas Hartman, Catharina A. Hemerich, Daiane Hofman, Albert Hottenga, Jouke-Jan Huikuri, Heikki Hutri-Kähönen, Nina Jouven, Xavier Junttila, Juhani Juonala, Markus Kiviniemi, Antti M. Kors, Jan A. Kumari, Meena Kuznetsova, Tatiana Laurie, Cathy C. Lefrandt, Joop D. Li, Yong Li, Yun Liao, Duanping Limacher, Marian C. Lin, Henry J. Lindgren, Cecilia M. Lubitz, Steven A. Mahajan, Anubha McKnight, Barbara zu Schwabedissen, Henriette Meyer Milaneschi, Yuri Mononen, Nina Morris, Andrew P. Nalls, Mike A. Navis, Gerjan Neijts, Melanie Nikus, Kjell North, Kari E. O'Connor, Daniel T. Ormel, Johan Perz, Siegfried Peters, Annette Psaty, Bruce M. Raitakari, Olli T. Risbrough, Victoria B. Sinner, Moritz F. Siscovick, David Smit, Johannes H. Smith, Nicholas L. Soliman, Elsayed Z. Sotoodehnia, Nona Staessen, Jan A. Stein, Phyllis K. Stilp, Adrienne M. Stolarz-Skrzypek, Katarzyna Strauch, Konstantin Sundström, Johan Swenne, Cees A. Syvänen, Ann-Christine Tardif, Jean-Claude Taylor, Kent D. Teumer, Alexander Thornton, Timothy A. Tinker, Lesley E. Uitterlinden, André G. van Setten, Jessica Voss, Andreas Waldenberger, Melanie Wilhelmsen, Kirk C. Willemsen, Gonneke Wong, Quenna Zhang, Zhu-Ming Zonderman, Alan B. Cusi, Daniele Evans, Michele K. Greiser, Halina K. van der Harst, Pim Hassan, Mohammad Ingelsson, Erik Järvelin, Marjo-Riitta Kääb, Stefan Kähönen, Mika Kivimaki, Mika Kooperberg, Charles Kuh, Diana Lehtimäki, Terho Lind, Lars Nievergelt, Caroline M. O'Donnell, Chris J. Oldehinkel, Albertine J. Penninx, Brenda Reiner, Alexander P. Riese, Harriëtte van Roon, Arie M. Rioux, John D. Rotter, Jerome I. Sofer, Tamar Stricker, Bruno H. Tiemeier, Henning Vrijkotte, Tanja G. M. Asselbergs, Folkert W. Brundel, Bianca J. J. M. Heckbert, Susan R. Whitsel, Eric A. den Hoed, Marcel Snieder, Harold de Geus, Eco J. C.
author_sort	Nolte, Ilja M.
collection	PubMed
description	Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74<r(g)<−0.55) and blood pressure (−0.35<r(g)<−0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.
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institution	National Center for Biotechnology Information
language	English
publishDate	2017
publisher	Nature Publishing Group
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spelling	pubmed-54747322017-07-03 Genetic loci associated with heart rate variability and their effects on cardiac disease risk Nolte, Ilja M. Munoz, M. Loretto Tragante, Vinicius Amare, Azmeraw T. Jansen, Rick Vaez, Ahmad von der Heyde, Benedikt Avery, Christy L. Bis, Joshua C. Dierckx, Bram van Dongen, Jenny Gogarten, Stephanie M. Goyette, Philippe Hernesniemi, Jussi Huikari, Ville Hwang, Shih-Jen Jaju, Deepali Kerr, Kathleen F. Kluttig, Alexander Krijthe, Bouwe P. Kumar, Jitender van der Laan, Sander W. Lyytikäinen, Leo-Pekka Maihofer, Adam X. Minassian, Arpi van der Most, Peter J. Müller-Nurasyid, Martina Nivard, Michel Salvi, Erika Stewart, James D. Thayer, Julian F. Verweij, Niek Wong, Andrew Zabaneh, Delilah Zafarmand, Mohammad H. Abdellaoui, Abdel Albarwani, Sulayma Albert, Christine Alonso, Alvaro Ashar, Foram Auvinen, Juha Axelsson, Tomas Baker, Dewleen G. de Bakker, Paul I. W. Barcella, Matteo Bayoumi, Riad Bieringa, Rob J. Boomsma, Dorret Boucher, Gabrielle Britton, Annie R. Christophersen, Ingrid Dietrich, Andrea Ehret, George B. Ellinor, Patrick T. Eskola, Markku Felix, Janine F. Floras, John S. Franco, Oscar H. Friberg, Peter Gademan, Maaike G. J. Geyer, Mark A. Giedraitis, Vilmantas Hartman, Catharina A. Hemerich, Daiane Hofman, Albert Hottenga, Jouke-Jan Huikuri, Heikki Hutri-Kähönen, Nina Jouven, Xavier Junttila, Juhani Juonala, Markus Kiviniemi, Antti M. Kors, Jan A. Kumari, Meena Kuznetsova, Tatiana Laurie, Cathy C. Lefrandt, Joop D. Li, Yong Li, Yun Liao, Duanping Limacher, Marian C. Lin, Henry J. Lindgren, Cecilia M. Lubitz, Steven A. Mahajan, Anubha McKnight, Barbara zu Schwabedissen, Henriette Meyer Milaneschi, Yuri Mononen, Nina Morris, Andrew P. Nalls, Mike A. Navis, Gerjan Neijts, Melanie Nikus, Kjell North, Kari E. O'Connor, Daniel T. Ormel, Johan Perz, Siegfried Peters, Annette Psaty, Bruce M. Raitakari, Olli T. Risbrough, Victoria B. Sinner, Moritz F. Siscovick, David Smit, Johannes H. Smith, Nicholas L. Soliman, Elsayed Z. Sotoodehnia, Nona Staessen, Jan A. Stein, Phyllis K. Stilp, Adrienne M. Stolarz-Skrzypek, Katarzyna Strauch, Konstantin Sundström, Johan Swenne, Cees A. Syvänen, Ann-Christine Tardif, Jean-Claude Taylor, Kent D. Teumer, Alexander Thornton, Timothy A. Tinker, Lesley E. Uitterlinden, André G. van Setten, Jessica Voss, Andreas Waldenberger, Melanie Wilhelmsen, Kirk C. Willemsen, Gonneke Wong, Quenna Zhang, Zhu-Ming Zonderman, Alan B. Cusi, Daniele Evans, Michele K. Greiser, Halina K. van der Harst, Pim Hassan, Mohammad Ingelsson, Erik Järvelin, Marjo-Riitta Kääb, Stefan Kähönen, Mika Kivimaki, Mika Kooperberg, Charles Kuh, Diana Lehtimäki, Terho Lind, Lars Nievergelt, Caroline M. O'Donnell, Chris J. Oldehinkel, Albertine J. Penninx, Brenda Reiner, Alexander P. Riese, Harriëtte van Roon, Arie M. Rioux, John D. Rotter, Jerome I. Sofer, Tamar Stricker, Bruno H. Tiemeier, Henning Vrijkotte, Tanja G. M. Asselbergs, Folkert W. Brundel, Bianca J. J. M. Heckbert, Susan R. Whitsel, Eric A. den Hoed, Marcel Snieder, Harold de Geus, Eco J. C. Nat Commun Article Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74<r(g)<−0.55) and blood pressure (−0.35<r(g)<−0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization. Nature Publishing Group 2017-06-14 /pmc/articles/PMC5474732/ /pubmed/28613276 http://dx.doi.org/10.1038/ncomms15805 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle	Article Nolte, Ilja M. Munoz, M. Loretto Tragante, Vinicius Amare, Azmeraw T. Jansen, Rick Vaez, Ahmad von der Heyde, Benedikt Avery, Christy L. Bis, Joshua C. Dierckx, Bram van Dongen, Jenny Gogarten, Stephanie M. Goyette, Philippe Hernesniemi, Jussi Huikari, Ville Hwang, Shih-Jen Jaju, Deepali Kerr, Kathleen F. Kluttig, Alexander Krijthe, Bouwe P. Kumar, Jitender van der Laan, Sander W. Lyytikäinen, Leo-Pekka Maihofer, Adam X. Minassian, Arpi van der Most, Peter J. Müller-Nurasyid, Martina Nivard, Michel Salvi, Erika Stewart, James D. Thayer, Julian F. Verweij, Niek Wong, Andrew Zabaneh, Delilah Zafarmand, Mohammad H. Abdellaoui, Abdel Albarwani, Sulayma Albert, Christine Alonso, Alvaro Ashar, Foram Auvinen, Juha Axelsson, Tomas Baker, Dewleen G. de Bakker, Paul I. W. Barcella, Matteo Bayoumi, Riad Bieringa, Rob J. Boomsma, Dorret Boucher, Gabrielle Britton, Annie R. Christophersen, Ingrid Dietrich, Andrea Ehret, George B. Ellinor, Patrick T. Eskola, Markku Felix, Janine F. Floras, John S. Franco, Oscar H. Friberg, Peter Gademan, Maaike G. J. Geyer, Mark A. Giedraitis, Vilmantas Hartman, Catharina A. Hemerich, Daiane Hofman, Albert Hottenga, Jouke-Jan Huikuri, Heikki Hutri-Kähönen, Nina Jouven, Xavier Junttila, Juhani Juonala, Markus Kiviniemi, Antti M. Kors, Jan A. Kumari, Meena Kuznetsova, Tatiana Laurie, Cathy C. Lefrandt, Joop D. Li, Yong Li, Yun Liao, Duanping Limacher, Marian C. Lin, Henry J. Lindgren, Cecilia M. Lubitz, Steven A. Mahajan, Anubha McKnight, Barbara zu Schwabedissen, Henriette Meyer Milaneschi, Yuri Mononen, Nina Morris, Andrew P. Nalls, Mike A. Navis, Gerjan Neijts, Melanie Nikus, Kjell North, Kari E. O'Connor, Daniel T. Ormel, Johan Perz, Siegfried Peters, Annette Psaty, Bruce M. Raitakari, Olli T. Risbrough, Victoria B. Sinner, Moritz F. Siscovick, David Smit, Johannes H. Smith, Nicholas L. Soliman, Elsayed Z. Sotoodehnia, Nona Staessen, Jan A. Stein, Phyllis K. Stilp, Adrienne M. Stolarz-Skrzypek, Katarzyna Strauch, Konstantin Sundström, Johan Swenne, Cees A. Syvänen, Ann-Christine Tardif, Jean-Claude Taylor, Kent D. Teumer, Alexander Thornton, Timothy A. Tinker, Lesley E. Uitterlinden, André G. van Setten, Jessica Voss, Andreas Waldenberger, Melanie Wilhelmsen, Kirk C. Willemsen, Gonneke Wong, Quenna Zhang, Zhu-Ming Zonderman, Alan B. Cusi, Daniele Evans, Michele K. Greiser, Halina K. van der Harst, Pim Hassan, Mohammad Ingelsson, Erik Järvelin, Marjo-Riitta Kääb, Stefan Kähönen, Mika Kivimaki, Mika Kooperberg, Charles Kuh, Diana Lehtimäki, Terho Lind, Lars Nievergelt, Caroline M. O'Donnell, Chris J. Oldehinkel, Albertine J. Penninx, Brenda Reiner, Alexander P. Riese, Harriëtte van Roon, Arie M. Rioux, John D. Rotter, Jerome I. Sofer, Tamar Stricker, Bruno H. Tiemeier, Henning Vrijkotte, Tanja G. M. Asselbergs, Folkert W. Brundel, Bianca J. J. M. Heckbert, Susan R. Whitsel, Eric A. den Hoed, Marcel Snieder, Harold de Geus, Eco J. C. Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title	Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title_full	Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title_fullStr	Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title_full_unstemmed	Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title_short	Genetic loci associated with heart rate variability and their effects on cardiac disease risk
title_sort	genetic loci associated with heart rate variability and their effects on cardiac disease risk
topic	Article
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732/ https://www.ncbi.nlm.nih.gov/pubmed/28613276 http://dx.doi.org/10.1038/ncomms15805
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geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT dietrichandrea geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT ehretgeorgeb geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT ellinorpatrickt geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT eskolamarkku geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT felixjaninef geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT florasjohns geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT francooscarh geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT fribergpeter geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT gademanmaaikegj geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT geyermarka geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT giedraitisvilmantas geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hartmancatharinaa geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hemerichdaiane geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hofmanalbert geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hottengajoukejan geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT huikuriheikki geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hutrikahonennina geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT jouvenxavier geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT junttilajuhani geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT juonalamarkus geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kiviniemianttim geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT korsjana geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kumarimeena geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kuznetsovatatiana geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lauriecathyc geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lefrandtjoopd geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT liyong geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT liyun geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT liaoduanping geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT limachermarianc geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT linhenryj geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lindgrenceciliam geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lubitzstevena geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT mahajananubha geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT mcknightbarbara geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT zuschwabedissenhenriettemeyer geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT milaneschiyuri geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT mononennina geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT morrisandrewp geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT nallsmikea geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT navisgerjan geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT neijtsmelanie geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT nikuskjell geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT northkarie geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT oconnordanielt geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT ormeljohan geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT perzsiegfried geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT petersannette geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT psatybrucem geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT raitakariollit geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT risbroughvictoriab geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT sinnermoritzf geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT siscovickdavid geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT smitjohannesh geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT smithnicholasl geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT solimanelsayedz geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT sotoodehnianona geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT staessenjana geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT steinphyllisk geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT stilpadriennem geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT stolarzskrzypekkatarzyna geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT strauchkonstantin geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT sundstromjohan geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT swenneceesa geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT syvanenannchristine geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT tardifjeanclaude geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT taylorkentd geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT teumeralexander geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT thorntontimothya geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT tinkerlesleye geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT uitterlindenandreg geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT vansettenjessica geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT vossandreas geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT waldenbergermelanie geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT wilhelmsenkirkc geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT willemsengonneke geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT wongquenna geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT zhangzhuming geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT zondermanalanb geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT cusidaniele geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT evansmichelek geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT greiserhalinak geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT vanderharstpim geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT hassanmohammad geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT ingelssonerik geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT jarvelinmarjoriitta geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kaabstefan geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kahonenmika geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kivimakimika geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kooperbergcharles geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT kuhdiana geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lehtimakiterho geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT lindlars geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT nievergeltcarolinem geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT odonnellchrisj geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT oldehinkelalbertinej geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT penninxbrenda geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT reineralexanderp geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT rieseharriette geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT vanroonariem geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT riouxjohnd geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT rotterjeromei geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT sofertamar geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT strickerbrunoh geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT tiemeierhenning geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT vrijkottetanjagm geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT asselbergsfolkertw geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT brundelbiancajjm geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT heckbertsusanr geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT whitselerica geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT denhoedmarcel geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT sniederharold geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk AT degeusecojc geneticlociassociatedwithheartratevariabilityandtheireffectsoncardiacdiseaserisk

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

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