The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Adult and fetal hematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial respiration is required to maintain HSC function is not known. Here we report that loss of the mitochondrial complex III subunit Rieske iron s...

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Detalles Bibliográficos
Autores principales: Ansó, Elena, Weinberg, Samuel E., Diebold, Lauren P., Thompson, Benjamin J., Malinge, Sébastien, Schumacker, Paul T., Liu, Xin, Zhang, Yuannyu, Shao, Zhen, Steadman, Mya, Marsh, Kelly M., Xu, Jian, Crispino, John D., Chandel, Navdeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474760/
https://www.ncbi.nlm.nih.gov/pubmed/28504706
http://dx.doi.org/10.1038/ncb3529

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