Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis

BACKGROUND: Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive pain crises (VOC) in SCD patients. METHODS: Fourteen adults on hydroxyurea with...

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Detalles Bibliográficos
Autores principales: Brandalise, Silvia R., Assis, Rosemary, Laranjeira, Angelo B. A., Yunes, José Andrés, de Campos-Lima, Pedro O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474854/
https://www.ncbi.nlm.nih.gov/pubmed/28638723
http://dx.doi.org/10.1186/s40164-017-0078-1

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