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Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human...

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Detalles Bibliográficos
Autores principales:	Ward, Thomas A., McHugh, Peter J., Durant, Stephen T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476263/ https://www.ncbi.nlm.nih.gov/pubmed/28628639 http://dx.doi.org/10.1371/journal.pone.0179278

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