A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC(1)D-Driven Transgene Expression in AAV-Mediated Gene Transfer

Experimentally restricting transgene expression exclusively to astrocytes has proven difficult. Using adeno-associated-virus-mediated gene transfer, we assessed two commonly used glial fibrillary acidic protein promoters: the full-length version gfa2 (2,210-bp human glial fibrillary acidic protein [...

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Detalles Bibliográficos
Autores principales: Taschenberger, Grit, Tereshchenko, Julia, Kügler, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476465/
https://www.ncbi.nlm.nih.gov/pubmed/28918015
http://dx.doi.org/10.1016/j.omtn.2017.03.009

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