Cargando…
HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death
The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function. Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the involveme...
Autores principales: | Okamoto, Akihisa, Sumi, Chisato, Tanaka, Hiromasa, Kusunoki, Munenori, Iwai, Teppei, Nishi, Kenichiro, Matsuo, Yoshiyuki, Harada, Hiroshi, Takenaga, Keizo, Bono, Hidemasa, Hirota, Kiichi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476559/ https://www.ncbi.nlm.nih.gov/pubmed/28630416 http://dx.doi.org/10.1038/s41598-017-03980-7 |
Ejemplares similares
-
Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity
por: Sumi, Chisato, et al.
Publicado: (2018) -
The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells
por: Okamoto, Akihisa, et al.
Publicado: (2016) -
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma
por: Sumi, Chisato, et al.
Publicado: (2019) -
Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner
por: Sumi, Chisato, et al.
Publicado: (2018) -
Propofol inhibits stromatoxin-1-sensitive voltage-dependent K(+) channels in pancreatic β-cells and enhances insulin secretion
por: Kusunoki, Munenori, et al.
Publicado: (2019)