IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection

Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associated with a poor treatment response. In the present study, we investigated the induction a...

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Detalles Bibliográficos
Autores principales: Sung, Pil Soo, Hong, Seon-Hui, Chung, Jae-Hee, Kim, Sojeong, Park, Su-Hyung, Kim, Ho Min, Yoon, Seung Kew, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476576/
https://www.ncbi.nlm.nih.gov/pubmed/28630501
http://dx.doi.org/10.1038/s41598-017-04186-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476576/
https://www.ncbi.nlm.nih.gov/pubmed/28630501
http://dx.doi.org/10.1038/s41598-017-04186-7

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