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IFN-λ4 potently blocks IFN-α signalling by ISG15 and USP18 in hepatitis C virus infection
Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associated with a poor treatment response. In the present study, we investigated the induction a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476576/ https://www.ncbi.nlm.nih.gov/pubmed/28630501 http://dx.doi.org/10.1038/s41598-017-04186-7 |