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Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass

BACKGROUND: The strong link between reduced muscle mass and morbidity and mortality highlights the urgent need for simple techniques that can monitor change in skeletal muscle cross‐sectional area (CSA). Our objective was to examine the validity of panoramic ultrasound to detect change in quadriceps...

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Autores principales: Scott, Jessica M., Martin, David S., Ploutz‐Snyder, Robert, Matz, Timothy, Caine, Timothy, Downs, Meghan, Hackney, Kyle, Buxton, Roxanne, Ryder, Jeffrey W., Ploutz‐Snyder, Lori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476852/
https://www.ncbi.nlm.nih.gov/pubmed/28052593
http://dx.doi.org/10.1002/jcsm.12172
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author Scott, Jessica M.
Martin, David S.
Ploutz‐Snyder, Robert
Matz, Timothy
Caine, Timothy
Downs, Meghan
Hackney, Kyle
Buxton, Roxanne
Ryder, Jeffrey W.
Ploutz‐Snyder, Lori
author_facet Scott, Jessica M.
Martin, David S.
Ploutz‐Snyder, Robert
Matz, Timothy
Caine, Timothy
Downs, Meghan
Hackney, Kyle
Buxton, Roxanne
Ryder, Jeffrey W.
Ploutz‐Snyder, Lori
author_sort Scott, Jessica M.
collection PubMed
description BACKGROUND: The strong link between reduced muscle mass and morbidity and mortality highlights the urgent need for simple techniques that can monitor change in skeletal muscle cross‐sectional area (CSA). Our objective was to examine the validity of panoramic ultrasound to detect change in quadriceps and gastrocnemius size in comparison with magnetic resonance imaging (MRI) in subjects randomized to 70 days of bed rest (BR) with or without exercise. METHODS: Panoramic ultrasound and MRI images of the quadriceps and gastrocnemius muscles were acquired on the right leg of 27 subjects (26 male, 1 female; age: 34.6 ± 7.8 years; body mass: 77.5 ± 10.0 kg; body mass index: 24.2 ± 2.8 kg/m(2); height: 179.1 ± 6.9 cm) before (BR‐6), during (BR3, 7, 11, 15, 22, 29, 36, 53, 69), and after (BR+3, +6, +10) BR. Validity of panoramic ultrasound to detect change in muscle CSA was assessed by Bland–Altman plots, Lin's concordance correlation coefficient (CCC), sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: Six hundred ninety‐eight panoramic ultrasound CSA and 698 MRI CSA measurements were assessed. Concordance between ultrasound and MRI was excellent in the quadriceps (CCC: 0.78; P < 0.0001), whereas there was poor concordance in the gastrocnemius (CCC: 0.37; P < 0.0006). Compared with MRI, panoramic ultrasound demonstrated high accuracy in detecting quadriceps atrophy and hypertrophy (sensitivity: 73.7%; specificity: 74.2%) and gastrocnemius atrophy (sensitivity: 83.1%) and low accuracy in detecting gastrocnemius hypertrophy (specificity: 33.0%). CONCLUSIONS: Panoramic ultrasound imaging is a valid tool for monitoring quadriceps muscle atrophy and hypertrophy and for detecting gastrocnemius atrophy.
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spelling pubmed-54768522017-06-23 Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass Scott, Jessica M. Martin, David S. Ploutz‐Snyder, Robert Matz, Timothy Caine, Timothy Downs, Meghan Hackney, Kyle Buxton, Roxanne Ryder, Jeffrey W. Ploutz‐Snyder, Lori J Cachexia Sarcopenia Muscle Original Articles BACKGROUND: The strong link between reduced muscle mass and morbidity and mortality highlights the urgent need for simple techniques that can monitor change in skeletal muscle cross‐sectional area (CSA). Our objective was to examine the validity of panoramic ultrasound to detect change in quadriceps and gastrocnemius size in comparison with magnetic resonance imaging (MRI) in subjects randomized to 70 days of bed rest (BR) with or without exercise. METHODS: Panoramic ultrasound and MRI images of the quadriceps and gastrocnemius muscles were acquired on the right leg of 27 subjects (26 male, 1 female; age: 34.6 ± 7.8 years; body mass: 77.5 ± 10.0 kg; body mass index: 24.2 ± 2.8 kg/m(2); height: 179.1 ± 6.9 cm) before (BR‐6), during (BR3, 7, 11, 15, 22, 29, 36, 53, 69), and after (BR+3, +6, +10) BR. Validity of panoramic ultrasound to detect change in muscle CSA was assessed by Bland–Altman plots, Lin's concordance correlation coefficient (CCC), sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: Six hundred ninety‐eight panoramic ultrasound CSA and 698 MRI CSA measurements were assessed. Concordance between ultrasound and MRI was excellent in the quadriceps (CCC: 0.78; P < 0.0001), whereas there was poor concordance in the gastrocnemius (CCC: 0.37; P < 0.0006). Compared with MRI, panoramic ultrasound demonstrated high accuracy in detecting quadriceps atrophy and hypertrophy (sensitivity: 73.7%; specificity: 74.2%) and gastrocnemius atrophy (sensitivity: 83.1%) and low accuracy in detecting gastrocnemius hypertrophy (specificity: 33.0%). CONCLUSIONS: Panoramic ultrasound imaging is a valid tool for monitoring quadriceps muscle atrophy and hypertrophy and for detecting gastrocnemius atrophy. John Wiley and Sons Inc. 2017-01-03 2017-06 /pmc/articles/PMC5476852/ /pubmed/28052593 http://dx.doi.org/10.1002/jcsm.12172 Text en © 2017 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Scott, Jessica M.
Martin, David S.
Ploutz‐Snyder, Robert
Matz, Timothy
Caine, Timothy
Downs, Meghan
Hackney, Kyle
Buxton, Roxanne
Ryder, Jeffrey W.
Ploutz‐Snyder, Lori
Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title_full Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title_fullStr Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title_full_unstemmed Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title_short Panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
title_sort panoramic ultrasound: a novel and valid tool for monitoring change in muscle mass
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476852/
https://www.ncbi.nlm.nih.gov/pubmed/28052593
http://dx.doi.org/10.1002/jcsm.12172
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