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Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy

Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic...

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Detalles Bibliográficos
Autores principales: Kezić, Aleksandra, Stajic, Natasa, Thaiss, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476886/
https://www.ncbi.nlm.nih.gov/pubmed/28676864
http://dx.doi.org/10.1155/2017/6305439
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author Kezić, Aleksandra
Stajic, Natasa
Thaiss, Friedrich
author_facet Kezić, Aleksandra
Stajic, Natasa
Thaiss, Friedrich
author_sort Kezić, Aleksandra
collection PubMed
description Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy. Alloantigen-independent inflammation is an important process, participating in pathogenesis of injurious response, caused by ischemia and reperfusion. This innate immune response is characterized by the activity of classical cells belonging to the immune system, such as neutrophils, macrophages, dendritic cells, lymphocytes, and also tubular epithelial cells and endothelial cells. These immune cells not only participate in inflammation after ischemia exerting detrimental influence but also play a protective role in the healing response from ischemia/reperfusion injury. Delineating of complex mechanisms of their actions could be fruitful in future prevention and treatment of ischemia/reperfusion injury. Among numerous so far conducted experiments, observed immunomodulatory role of adenosine and adenosine receptor agonists in complex interactions of dendritic cells, natural killer T cells, and T regulatory cells is emphasized as promising in the treatment of kidney ischemia/reperfusion injury. Potential pharmacological approaches which decrease NF-κB activity and antagonize mechanisms downstream of activated Toll-like receptors are discussed.
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spelling pubmed-54768862017-07-04 Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy Kezić, Aleksandra Stajic, Natasa Thaiss, Friedrich J Immunol Res Review Article Acute kidney injury caused by ischemia and subsequent reperfusion is associated with a high rate of mortality and morbidity. Ischemia/reperfusion injury in kidney transplantation causes delayed graft function and is associated with more frequent episodes of acute rejection and progression to chronic allograft nephropathy. Alloantigen-independent inflammation is an important process, participating in pathogenesis of injurious response, caused by ischemia and reperfusion. This innate immune response is characterized by the activity of classical cells belonging to the immune system, such as neutrophils, macrophages, dendritic cells, lymphocytes, and also tubular epithelial cells and endothelial cells. These immune cells not only participate in inflammation after ischemia exerting detrimental influence but also play a protective role in the healing response from ischemia/reperfusion injury. Delineating of complex mechanisms of their actions could be fruitful in future prevention and treatment of ischemia/reperfusion injury. Among numerous so far conducted experiments, observed immunomodulatory role of adenosine and adenosine receptor agonists in complex interactions of dendritic cells, natural killer T cells, and T regulatory cells is emphasized as promising in the treatment of kidney ischemia/reperfusion injury. Potential pharmacological approaches which decrease NF-κB activity and antagonize mechanisms downstream of activated Toll-like receptors are discussed. Hindawi 2017 2017-06-06 /pmc/articles/PMC5476886/ /pubmed/28676864 http://dx.doi.org/10.1155/2017/6305439 Text en Copyright © 2017 Aleksandra Kezić et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kezić, Aleksandra
Stajic, Natasa
Thaiss, Friedrich
Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title_full Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title_fullStr Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title_full_unstemmed Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title_short Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy
title_sort innate immune response in kidney ischemia/reperfusion injury: potential target for therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476886/
https://www.ncbi.nlm.nih.gov/pubmed/28676864
http://dx.doi.org/10.1155/2017/6305439
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