Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017

With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled tryp...

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Detalles Bibliográficos
Autores principales: Zhu, Wenfei, Zhou, Jianfang, Li, Zi, Yang, Lei, Li, Xiyan, Huang, Weijuan, Zou, Sumei, Chen, Wenbing, Wei, Hejiang, Tang, Jing, Liu, Liqi, Dong, Jie, Wang, Dayan, Shu, Yuelong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476987/
https://www.ncbi.nlm.nih.gov/pubmed/28537546
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30533
Descripción
Sumario:With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype.

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