Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017

With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled tryp...

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Autores principales: Zhu, Wenfei, Zhou, Jianfang, Li, Zi, Yang, Lei, Li, Xiyan, Huang, Weijuan, Zou, Sumei, Chen, Wenbing, Wei, Hejiang, Tang, Jing, Liu, Liqi, Dong, Jie, Wang, Dayan, Shu, Yuelong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476987/
https://www.ncbi.nlm.nih.gov/pubmed/28537546
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30533
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author Zhu, Wenfei
Zhou, Jianfang
Li, Zi
Yang, Lei
Li, Xiyan
Huang, Weijuan
Zou, Sumei
Chen, Wenbing
Wei, Hejiang
Tang, Jing
Liu, Liqi
Dong, Jie
Wang, Dayan
Shu, Yuelong
author_facet Zhu, Wenfei
Zhou, Jianfang
Li, Zi
Yang, Lei
Li, Xiyan
Huang, Weijuan
Zou, Sumei
Chen, Wenbing
Wei, Hejiang
Tang, Jing
Liu, Liqi
Dong, Jie
Wang, Dayan
Shu, Yuelong
author_sort Zhu, Wenfei
collection PubMed
description With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype.
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spelling pubmed-54769872017-07-03 Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017 Zhu, Wenfei Zhou, Jianfang Li, Zi Yang, Lei Li, Xiyan Huang, Weijuan Zou, Sumei Chen, Wenbing Wei, Hejiang Tang, Jing Liu, Liqi Dong, Jie Wang, Dayan Shu, Yuelong Euro Surveill Rapid Communication With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections in humans. In the current fifth epidemic wave, a highly pathogenic avian influenza (HPAI) H7N9 virus emerged. The insertion of four amino acids (KRTA) at the haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity of this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic avian influenza A(H7N9). The neuraminidase substitution R292K conferred a multidrug resistance phenotype. European Centre for Disease Prevention and Control (ECDC) 2017-05-11 /pmc/articles/PMC5476987/ /pubmed/28537546 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30533 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Zhu, Wenfei
Zhou, Jianfang
Li, Zi
Yang, Lei
Li, Xiyan
Huang, Weijuan
Zou, Sumei
Chen, Wenbing
Wei, Hejiang
Tang, Jing
Liu, Liqi
Dong, Jie
Wang, Dayan
Shu, Yuelong
Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title_full Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title_fullStr Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title_full_unstemmed Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title_short Biological characterisation of the emerged highly pathogenic avian influenza (HPAI) A(H7N9) viruses in humans, in mainland China, 2016 to 2017
title_sort biological characterisation of the emerged highly pathogenic avian influenza (hpai) a(h7n9) viruses in humans, in mainland china, 2016 to 2017
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476987/
https://www.ncbi.nlm.nih.gov/pubmed/28537546
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.19.30533
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