The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper...

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Detalles Bibliográficos
Autores principales: Fox, J. C., Gilligan, R. E., Pitts, A. K., Bennett, H. R., Gaunt, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477024/
https://www.ncbi.nlm.nih.gov/pubmed/28660044
http://dx.doi.org/10.1039/c5sc04399a
Descripción
Sumario:A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper-catalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structural complexity of the natural product framework.

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