Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides

Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glyc...

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Detalles Bibliográficos
Autores principales: Moradi, Shayli Varasteh, Hussein, Waleed M., Varamini, Pegah, Simerska, Pavla, Toth, Istvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477030/
https://www.ncbi.nlm.nih.gov/pubmed/28660018
http://dx.doi.org/10.1039/c5sc04392a
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author Moradi, Shayli Varasteh
Hussein, Waleed M.
Varamini, Pegah
Simerska, Pavla
Toth, Istvan
author_facet Moradi, Shayli Varasteh
Hussein, Waleed M.
Varamini, Pegah
Simerska, Pavla
Toth, Istvan
author_sort Moradi, Shayli Varasteh
collection PubMed
description Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein.
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spelling pubmed-54770302017-06-28 Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides Moradi, Shayli Varasteh Hussein, Waleed M. Varamini, Pegah Simerska, Pavla Toth, Istvan Chem Sci Chemistry Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes. This review highlights various methods for the synthesis of glycoconjugates and recent progress in the development of glycosylated peptide therapeutics. Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein. Royal Society of Chemistry 2016-04-01 2016-01-29 /pmc/articles/PMC5477030/ /pubmed/28660018 http://dx.doi.org/10.1039/c5sc04392a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Moradi, Shayli Varasteh
Hussein, Waleed M.
Varamini, Pegah
Simerska, Pavla
Toth, Istvan
Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title_full Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title_fullStr Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title_full_unstemmed Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title_short Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
title_sort glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477030/
https://www.ncbi.nlm.nih.gov/pubmed/28660018
http://dx.doi.org/10.1039/c5sc04392a
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AT varaminipegah glycosylationaneffectivesyntheticstrategytoimprovethebioavailabilityoftherapeuticpeptides
AT simerskapavla glycosylationaneffectivesyntheticstrategytoimprovethebioavailabilityoftherapeuticpeptides
AT tothistvan glycosylationaneffectivesyntheticstrategytoimprovethebioavailabilityoftherapeuticpeptides

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