Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds

Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin containing four disulfide bridges, is a high affinity blocker of the voltage-gated potassium channel Kv1.3, but also blocks Kv1.2. To improve potential therapeutic use of the toxin, we have designed a double substituted analog, [N17A/F32T]-AnTx, whi...

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Detalles Bibliográficos
Autores principales: Fehér, Krisztina, Timári, István, Rákosi, Kinga, Szolomájer, János, Illyés, Tünde Z., Bartok, Adam, Varga, Zoltan, Panyi, Gyorgy, Tóth, Gábor K., Kövér, Katalin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477041/
https://www.ncbi.nlm.nih.gov/pubmed/28660039
http://dx.doi.org/10.1039/c5sc03995a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477041/
https://www.ncbi.nlm.nih.gov/pubmed/28660039
http://dx.doi.org/10.1039/c5sc03995a

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