Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile

The direct cyanomethylation of unactivated sp(3) C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C–H bonds with acetoni...

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Detalles Bibliográficos
Autores principales: Liu, Yongbing, Yang, Ke, Ge, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477045/
https://www.ncbi.nlm.nih.gov/pubmed/28660057
http://dx.doi.org/10.1039/c5sc04066c
Descripción
Sumario:The direct cyanomethylation of unactivated sp(3) C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.

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