Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile

The direct cyanomethylation of unactivated sp(3) C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C–H bonds with acetoni...

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Detalles Bibliográficos
Autores principales: Liu, Yongbing, Yang, Ke, Ge, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477045/
https://www.ncbi.nlm.nih.gov/pubmed/28660057
http://dx.doi.org/10.1039/c5sc04066c
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author Liu, Yongbing
Yang, Ke
Ge, Haibo
author_facet Liu, Yongbing
Yang, Ke
Ge, Haibo
author_sort Liu, Yongbing
collection PubMed
description The direct cyanomethylation of unactivated sp(3) C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.
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spelling pubmed-54770452017-06-28 Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile Liu, Yongbing Yang, Ke Ge, Haibo Chem Sci Chemistry The direct cyanomethylation of unactivated sp(3) C–H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp(3) C–H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research. Royal Society of Chemistry 2016-04-01 2016-01-06 /pmc/articles/PMC5477045/ /pubmed/28660057 http://dx.doi.org/10.1039/c5sc04066c Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Liu, Yongbing
Yang, Ke
Ge, Haibo
Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title_full Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title_fullStr Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title_full_unstemmed Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title_short Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp(3))–H bonds with acetonitrile
title_sort palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated c(sp(3))–h bonds with acetonitrile
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477045/
https://www.ncbi.nlm.nih.gov/pubmed/28660057
http://dx.doi.org/10.1039/c5sc04066c
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AT yangke palladiumcatalyzedligandpromotedsiteselectivecyanomethylationofunactivatedcsp3hbondswithacetonitrile
AT gehaibo palladiumcatalyzedligandpromotedsiteselectivecyanomethylationofunactivatedcsp3hbondswithacetonitrile

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