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Depletion of p21-activated kinase 1 up-regulates the immune system of APC(∆14/+) mice and inhibits intestinal tumorigenesis

BACKGROUND: P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. The aim of this study was to investiga...

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Detalles Bibliográficos
Autores principales:	Huynh, Nhi, Wang, Kai, Yim, Mildred, Dumesny, Chelsea J., Sandrin, Mauro S., Baldwin, Graham S., Nikfarjam, Mehrdad, He, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477105/ https://www.ncbi.nlm.nih.gov/pubmed/28629331 http://dx.doi.org/10.1186/s12885-017-3432-0

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