Cargando…

Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

BACKGROUND: Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing. METHODS: To identify oncogenic genomic rearrangements and re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greer, Stephanie U., Nadauld, Lincoln D., Lau, Billy T., Chen, Jiamin, Wood-Bouwens, Christina, Ford, James M., Kuo, Calvin J., Ji, Hanlee P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477353/ https://www.ncbi.nlm.nih.gov/pubmed/28629429 http://dx.doi.org/10.1186/s13073-017-0447-8

Ejemplares similares

Identification of large rearrangements in cancer genomes with barcode linked reads
por: Xia, Li C, et al.
Publicado: (2018)

Single-cell transcriptome analysis identifies distinct cell types and niche signaling in a primary gastric organoid model
por: Chen, Jiamin, et al.
Publicado: (2019)

Precision Oncology Strategy in Trastuzumab-Resistant Human Epidermal Growth Factor Receptor 2–Positive Colon Cancer: Case Report of Durable Response to Ado-Trastuzumab Emtansine
por: Haslem, Derrick S., et al.
Publicado: (2017)

Chromosome-scale mega-haplotypes enable digital karyotyping of cancer aneuploidy
por: Bell, John M., et al.
Publicado: (2017)

Whole genome analysis identifies the association of TP53 genomic deletions with lower survival in Stage III colorectal cancer
por: Xia, Li C., et al.
Publicado: (2020)

Characterization of the consensus mucosal microbiome of colorectal cancer
por: Zhao, Lan, et al.
Publicado: (2021)

Single-Color Digital PCR Provides High-Performance Detection of Cancer Mutations from Circulating DNA
por: Wood-Bouwens, Christina, et al.
Publicado: (2017)

A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer
por: Chen, Jiamin, et al.
Publicado: (2019)

Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62
por: Greer, Stephanie U., et al.
Publicado: (2022)

Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer
por: Nadauld, Lincoln D, et al.
Publicado: (2014)

Single molecule counting and assessment of random molecular tagging errors with transposable giga-scale error-correcting barcodes
por: Lau, Billy T., et al.
Publicado: (2017)

Resolving the full spectrum of human genome variation using Linked-Reads
por: Marks, Patrick, et al.
Publicado: (2019)

Single cell and spatial alternative splicing analysis with long read sequencing
por: Fu, Yuntian, et al.
Publicado: (2023)

Single-cell multi-gene identification of somatic mutations and gene rearrangements in cancer
por: Grimes, Susan M, et al.
Publicado: (2023)

Targeted short read sequencing and assembly of re-arrangements and candidate gene loci provide megabase diplotypes
por: Shin, GiWon, et al.
Publicado: (2019)

Linked-Read Whole Genome Sequencing Solves a Double DMD Gene Rearrangement
por: Onore, Maria Elena, et al.
Publicado: (2021)

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution
por: Andor, Noemi, et al.
Publicado: (2020)

Finding the missing link: Resolving the Coryneliomycetidae within Eurotiomycetes
por: Wood, A.R., et al.
Publicado: (2015)

High Sensitivity Detection and Quantitation of DNA Copy Number and Single Nucleotide Variants with Single Color Droplet Digital PCR
por: Miotke, Laura, et al.
Publicado: (2014)

Correction to High Sensitivity Detection and Quantitation of DNA Copy Number and Single Nucleotide Variants with Single Color Droplet Digital PCR
por: Miotke, Laura, et al.
Publicado: (2014)

Correction to High Sensitivity Detection and Quantitation of DNA Copy Number and Single Nucleotide Variants with Single Color Droplet Digital PCR
por: Miotke, Laura, et al.
Publicado: (2015)

Resolving repeat families with long reads
por: Bongartz, Philipp
Publicado: (2019)

Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
por: Peña-Pérez, Lucía, et al.
Publicado: (2022)

Haplotyping germline and cancer genomes using high-throughput linked-read sequencing
por: Zheng, Grace X.Y., et al.
Publicado: (2016)

Resolving complex structural genomic rearrangements using a randomized approach
por: Zhao, Xuefang, et al.
Publicado: (2016)

Clinical Utility of Genomic Testing in Cancer Care
por: Pritchard, Daryl, et al.
Publicado: (2022)

Evolution of structural rearrangements in prostate cancer intracranial metastases
por: Khani, Francesca, et al.
Publicado: (2023)

An effective method to resolve ambiguous bisulfite-treated reads
por: Liu, Mengya, et al.
Publicado: (2021)

Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing
por: Pham, Minh-Tam, et al.
Publicado: (2022)

Haplotype-resolved and integrated genome analysis of the cancer cell line HepG2
por: Zhou, Bo, et al.
Publicado: (2019)

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
por: Ringel, Alessa R., et al.
Publicado: (2022)

Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1(+) Macrophages and Fibroblasts
por: Sathe, Anuja, et al.
Publicado: (2023)

Editorial: Resolving the Complexity of Plant Genomes and Transcriptomes With Long Reads
por: Zmienko, Agnieszka, et al.
Publicado: (2022)

Single-cell characterization of CRISPR-modified transcript isoforms with nanopore sequencing
por: Kim, Heon Seok, et al.
Publicado: (2021)

Reversible rearrangement of magnetic nanoparticles in solution studied using time-resolved SAXS method
por: Huang, Lanqing, et al.
Publicado: (2019)

Magnetic DNA random access memory with nanopore readouts and exponentially-scaled combinatorial addressing
por: Lau, Billy, et al.
Publicado: (2023)

Author Correction: Evolution of structural rearrangements in prostate cancer intracranial metastases
por: Khani, Francesca, et al.
Publicado: (2023)

Endobronchial Metastases in Lung Cancer Harboring EML4-ALK Rearrangement
por: Ijichi, Miharu, et al.
Publicado: (2022)

Analysis of genomic rearrangements by using the Burrows-Wheeler transform of short-read data
por: Kimura, Kouichi, et al.
Publicado: (2015)

SIGAR: Inferring Features of Genome Architecture and DNA Rearrangements by Split-Read Mapping
por: Feng, Yi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_a90p6mr0u8g0mouti7lcou6uqh