Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature

BACKGROUND: Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in ph...

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Autores principales: Venturin, C., Nancey, S., Danion, P., Uzzan, M., Chauvenet, M., Bergoin, C., Roblin, X., Flourié, B., Boschetti, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477379/
https://www.ncbi.nlm.nih.gov/pubmed/28629323
http://dx.doi.org/10.1186/s12876-017-0633-6
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author Venturin, C.
Nancey, S.
Danion, P.
Uzzan, M.
Chauvenet, M.
Bergoin, C.
Roblin, X.
Flourié, B.
Boschetti, G.
author_facet Venturin, C.
Nancey, S.
Danion, P.
Uzzan, M.
Chauvenet, M.
Bergoin, C.
Roblin, X.
Flourié, B.
Boschetti, G.
author_sort Venturin, C.
collection PubMed
description BACKGROUND: Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn’s disease (CD). CASE PRESENTATION: We report here the case of a patient who became pregnant during treatment with ustekinumab for a refractory CD and which ended in miscarriage. CONCLUSION: Ustekinumab is a relatively new pharmacotherapy and in addition to this clinical case, we reviewed the published literature concerning the use of this treatment during pregnancy and its consequences on pregnancy and fetus outcome.
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spelling pubmed-54773792017-06-23 Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature Venturin, C. Nancey, S. Danion, P. Uzzan, M. Chauvenet, M. Bergoin, C. Roblin, X. Flourié, B. Boschetti, G. BMC Gastroenterol Case Report BACKGROUND: Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoriasis and psoriatic arthritis treatment and has been successfully evaluated in phase II and III trials for patients with Crohn’s disease (CD). CASE PRESENTATION: We report here the case of a patient who became pregnant during treatment with ustekinumab for a refractory CD and which ended in miscarriage. CONCLUSION: Ustekinumab is a relatively new pharmacotherapy and in addition to this clinical case, we reviewed the published literature concerning the use of this treatment during pregnancy and its consequences on pregnancy and fetus outcome. BioMed Central 2017-06-19 /pmc/articles/PMC5477379/ /pubmed/28629323 http://dx.doi.org/10.1186/s12876-017-0633-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Venturin, C.
Nancey, S.
Danion, P.
Uzzan, M.
Chauvenet, M.
Bergoin, C.
Roblin, X.
Flourié, B.
Boschetti, G.
Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title_full Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title_fullStr Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title_full_unstemmed Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title_short Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature
title_sort fetal death in utero and miscarriage in a patient with crohn’s disease under therapy with ustekinumab: case-report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477379/
https://www.ncbi.nlm.nih.gov/pubmed/28629323
http://dx.doi.org/10.1186/s12876-017-0633-6
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