Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features

The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell...

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Detalles Bibliográficos
Autores principales: Conces, Miriam, Abu-Arja, Rolla, Reed, Suzanne, Rangarajan, Hemalatha G., Guinipero, Terri L., Loken, Michael R., Brodersen, Lisa Eidenschink, Kahwash, Samir B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477472/
https://www.ncbi.nlm.nih.gov/pubmed/28670435
http://dx.doi.org/10.4081/hr.2017.7057
Descripción
Sumario:The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype.

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