Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features

The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell...

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Autores principales: Conces, Miriam, Abu-Arja, Rolla, Reed, Suzanne, Rangarajan, Hemalatha G., Guinipero, Terri L., Loken, Michael R., Brodersen, Lisa Eidenschink, Kahwash, Samir B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477472/
https://www.ncbi.nlm.nih.gov/pubmed/28670435
http://dx.doi.org/10.4081/hr.2017.7057
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author Conces, Miriam
Abu-Arja, Rolla
Reed, Suzanne
Rangarajan, Hemalatha G.
Guinipero, Terri L.
Loken, Michael R.
Brodersen, Lisa Eidenschink
Kahwash, Samir B.
author_facet Conces, Miriam
Abu-Arja, Rolla
Reed, Suzanne
Rangarajan, Hemalatha G.
Guinipero, Terri L.
Loken, Michael R.
Brodersen, Lisa Eidenschink
Kahwash, Samir B.
author_sort Conces, Miriam
collection PubMed
description The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype.
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spelling pubmed-54774722017-06-30 Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features Conces, Miriam Abu-Arja, Rolla Reed, Suzanne Rangarajan, Hemalatha G. Guinipero, Terri L. Loken, Michael R. Brodersen, Lisa Eidenschink Kahwash, Samir B. Hematol Rep Case Report The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype. PAGEPress Publications, Pavia, Italy 2017-06-14 /pmc/articles/PMC5477472/ /pubmed/28670435 http://dx.doi.org/10.4081/hr.2017.7057 Text en ©Copyright M. Conces et al., 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Conces, Miriam
Abu-Arja, Rolla
Reed, Suzanne
Rangarajan, Hemalatha G.
Guinipero, Terri L.
Loken, Michael R.
Brodersen, Lisa Eidenschink
Kahwash, Samir B.
Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title_full Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title_fullStr Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title_full_unstemmed Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title_short Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features
title_sort acute myeloid leukemia with ram immunophenotype: a pediatric case with unusual morphologic features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477472/
https://www.ncbi.nlm.nih.gov/pubmed/28670435
http://dx.doi.org/10.4081/hr.2017.7057
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