EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression. Genome-wide associated studies have implicated EZH2 in the control of height and mutations in EZH2...

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Detalles Bibliográficos
Autores principales: Lui, Julian C., Garrison, Presley, Nguyen, Quang, Ad, Michal, Keembiyehetty, Chithra, Chen, Weiping, Jee, Youn Hee, Landman, Ellie, Nilsson, Ola, Barnes, Kevin M., Baron, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477487/
https://www.ncbi.nlm.nih.gov/pubmed/27897169
http://dx.doi.org/10.1038/ncomms13685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477487/
https://www.ncbi.nlm.nih.gov/pubmed/27897169
http://dx.doi.org/10.1038/ncomms13685

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