MICU1 drives glycolysis and chemoresistance in ovarian cancer

Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca(2+) uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer. We show th...

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Detalles Bibliográficos
Autores principales: Chakraborty, Prabir K., Mustafi, Soumyajit Banerjee, Xiong, Xunhao, Dwivedi, Shailendra Kumar Dhar, Nesin, Vasyl, Saha, Sounik, Zhang, Min, Dhanasekaran, Danny, Jayaraman, Muralidharan, Mannel, Robert, Moore, Kathleen, McMeekin, Scott, Yang, Da, Zuna, Rosemary, Ding, Kai, Tsiokas, Leonidas, Bhattacharya, Resham, Mukherjee, Priyabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477507/
https://www.ncbi.nlm.nih.gov/pubmed/28530221
http://dx.doi.org/10.1038/ncomms14634

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