Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individuals with ESCC. We identify six mutational signatures (E1–E6), and Signature E4 is unique in ESCC li...

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Detalles Bibliográficos
Autores principales: Chang, Jiang, Tan, Wenle, Ling, Zhiqiang, Xi, Ruibin, Shao, Mingming, Chen, Mengjie, Luo, Yingying, Zhao, Yanjie, Liu, Yun, Huang, Xiancong, Xia, Yuchao, Hu, Jinlin, Parker, Joel S., Marron, David, Cui, Qionghua, Peng, Linna, Chu, Jiahui, Li, Hongmin, Du, Zhongli, Han, Yaling, Tan, Wen, Liu, Zhihua, Zhan, Qimin, Li, Yun, Mao, Weimin, Wu, Chen, Lin, Dongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477513/
https://www.ncbi.nlm.nih.gov/pubmed/28548104
http://dx.doi.org/10.1038/ncomms15290

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