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A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic

Strigolactones are a class of plant hormones that inhibit axillary bud outgrowth and are released from plant roots to act as a rhizosphere communication signal. The Orobanchaceae parasitic plant Striga hermonthica perceives strigolactone as its germination signal, indicating host presence. After ger...

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Autores principales: Fukui, Kosuke, Yamagami, Daichi, Ito, Shinsaku, Asami, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477565/
https://www.ncbi.nlm.nih.gov/pubmed/28676802
http://dx.doi.org/10.3389/fpls.2017.00936
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author Fukui, Kosuke
Yamagami, Daichi
Ito, Shinsaku
Asami, Tadao
author_facet Fukui, Kosuke
Yamagami, Daichi
Ito, Shinsaku
Asami, Tadao
author_sort Fukui, Kosuke
collection PubMed
description Strigolactones are a class of plant hormones that inhibit axillary bud outgrowth and are released from plant roots to act as a rhizosphere communication signal. The Orobanchaceae parasitic plant Striga hermonthica perceives strigolactone as its germination signal, indicating host presence. After germination, the Striga plant parasitises the host plant and suppresses host growth by draining photosynthetic products, water and other essential nutrients. Because of this way of life, this parasite threatens crop production in sub-Saharan Africa with infestation in crop fields and crop devastation. Crop protection in such areas is among the most concerning problems to be dealt with as immediately as possible. With respect to crop protection from Striga, many strigolactone agonists have been developed and used in research to reveal Striga biology, and have contributed to development of crop protection methods. However, an effective method has yet to be found. In a previous study, we reported debranones as a group of strigolactone mimics that inhibit axillary buds outgrowth with moderate stimulation activity for Striga germination. Debranones would be accessible because they are simply synthesized from commercially available phenols and bromo butenolide. Taking this advantage of debranones for Striga research, we tried to find the debranones stimulating Striga seed germination. To modulate functional selectivity and to enhance germination inducing activity of debranones, we studied structure–activity relationships. We investigated effects of substituent position and functional group on debranone activity and selectivity as a strigolactone mimic. As a result, we improved stimulation activity of debranones for Striga seed germination by chemical modification, and demonstrated the pharmacophore of debranones for selective modulation of distinct strigolactone responses.
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spelling pubmed-54775652017-07-04 A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic Fukui, Kosuke Yamagami, Daichi Ito, Shinsaku Asami, Tadao Front Plant Sci Plant Science Strigolactones are a class of plant hormones that inhibit axillary bud outgrowth and are released from plant roots to act as a rhizosphere communication signal. The Orobanchaceae parasitic plant Striga hermonthica perceives strigolactone as its germination signal, indicating host presence. After germination, the Striga plant parasitises the host plant and suppresses host growth by draining photosynthetic products, water and other essential nutrients. Because of this way of life, this parasite threatens crop production in sub-Saharan Africa with infestation in crop fields and crop devastation. Crop protection in such areas is among the most concerning problems to be dealt with as immediately as possible. With respect to crop protection from Striga, many strigolactone agonists have been developed and used in research to reveal Striga biology, and have contributed to development of crop protection methods. However, an effective method has yet to be found. In a previous study, we reported debranones as a group of strigolactone mimics that inhibit axillary buds outgrowth with moderate stimulation activity for Striga germination. Debranones would be accessible because they are simply synthesized from commercially available phenols and bromo butenolide. Taking this advantage of debranones for Striga research, we tried to find the debranones stimulating Striga seed germination. To modulate functional selectivity and to enhance germination inducing activity of debranones, we studied structure–activity relationships. We investigated effects of substituent position and functional group on debranone activity and selectivity as a strigolactone mimic. As a result, we improved stimulation activity of debranones for Striga seed germination by chemical modification, and demonstrated the pharmacophore of debranones for selective modulation of distinct strigolactone responses. Frontiers Media S.A. 2017-06-20 /pmc/articles/PMC5477565/ /pubmed/28676802 http://dx.doi.org/10.3389/fpls.2017.00936 Text en Copyright © 2017 Fukui, Yamagami, Ito and Asami. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Fukui, Kosuke
Yamagami, Daichi
Ito, Shinsaku
Asami, Tadao
A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title_full A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title_fullStr A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title_full_unstemmed A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title_short A Taylor-Made Design of Phenoxyfuranone-Type Strigolactone Mimic
title_sort taylor-made design of phenoxyfuranone-type strigolactone mimic
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477565/
https://www.ncbi.nlm.nih.gov/pubmed/28676802
http://dx.doi.org/10.3389/fpls.2017.00936
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