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Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication

The role of the innate immune protein LGP2 (laboratory of genetics and physiology 2) in FMDV-infected cells remains unknown. Here, we demonstrate the antiviral role of LGP2 during FMDV infection. FMDV infection triggered LGP2 mRNA expression but reduced protein expression. Overexpression of LGP2 sup...

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Detalles Bibliográficos
Autores principales:	Zhu, Zixiang, Li, Chuntian, Du, Xiaoli, Wang, Guoqing, Cao, Weijun, Yang, Fan, Feng, Huanhuan, Zhang, Xiangle, Shi, Zhengwang, Liu, Huanan, Tian, Hong, Li, Dan, Zhang, Keshan, Liu, Xiangtao, Zheng, Haixue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477588/ https://www.ncbi.nlm.nih.gov/pubmed/28406479 http://dx.doi.org/10.1038/cddis.2017.170

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