Cargando…

Dissociation of Down syndrome and Alzheimer's disease effects with imaging

INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is...

Descripción completa

Detalles Bibliográficos
Autores principales: Matthews, Dawn C., Lukic, Ana S., Andrews, Randolph D., Marendic, Boris, Brewer, James, Rissman, Robert A., Mosconi, Lisa, Strother, Stephen C., Wernick, Miles N., Mobley, William C., Ness, Seth, Schmidt, Mark E., Rafii, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477635/
https://www.ncbi.nlm.nih.gov/pubmed/28642933
http://dx.doi.org/10.1016/j.trci.2016.02.004
_version_ 1783244828041019392
author Matthews, Dawn C.
Lukic, Ana S.
Andrews, Randolph D.
Marendic, Boris
Brewer, James
Rissman, Robert A.
Mosconi, Lisa
Strother, Stephen C.
Wernick, Miles N.
Mobley, William C.
Ness, Seth
Schmidt, Mark E.
Rafii, Michael S.
author_facet Matthews, Dawn C.
Lukic, Ana S.
Andrews, Randolph D.
Marendic, Boris
Brewer, James
Rissman, Robert A.
Mosconi, Lisa
Strother, Stephen C.
Wernick, Miles N.
Mobley, William C.
Ness, Seth
Schmidt, Mark E.
Rafii, Michael S.
author_sort Matthews, Dawn C.
collection PubMed
description INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects. METHODS: We evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods. RESULTS: Our results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures. DISCUSSION: These findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults.
format Online
Article
Text
id pubmed-5477635
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-54776352017-06-20 Dissociation of Down syndrome and Alzheimer's disease effects with imaging Matthews, Dawn C. Lukic, Ana S. Andrews, Randolph D. Marendic, Boris Brewer, James Rissman, Robert A. Mosconi, Lisa Strother, Stephen C. Wernick, Miles N. Mobley, William C. Ness, Seth Schmidt, Mark E. Rafii, Michael S. Alzheimers Dement (N Y) Featured Article INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects. METHODS: We evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods. RESULTS: Our results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures. DISCUSSION: These findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults. Elsevier 2016-03-08 /pmc/articles/PMC5477635/ /pubmed/28642933 http://dx.doi.org/10.1016/j.trci.2016.02.004 Text en © 2016 ADM Diagnostics http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Featured Article
Matthews, Dawn C.
Lukic, Ana S.
Andrews, Randolph D.
Marendic, Boris
Brewer, James
Rissman, Robert A.
Mosconi, Lisa
Strother, Stephen C.
Wernick, Miles N.
Mobley, William C.
Ness, Seth
Schmidt, Mark E.
Rafii, Michael S.
Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title_full Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title_fullStr Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title_full_unstemmed Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title_short Dissociation of Down syndrome and Alzheimer's disease effects with imaging
title_sort dissociation of down syndrome and alzheimer's disease effects with imaging
topic Featured Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477635/
https://www.ncbi.nlm.nih.gov/pubmed/28642933
http://dx.doi.org/10.1016/j.trci.2016.02.004
work_keys_str_mv AT matthewsdawnc dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT lukicanas dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT andrewsrandolphd dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT marendicboris dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT brewerjames dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT rissmanroberta dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT mosconilisa dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT strotherstephenc dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT wernickmilesn dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT mobleywilliamc dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT nessseth dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT schmidtmarke dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging
AT rafiimichaels dissociationofdownsyndromeandalzheimersdiseaseeffectswithimaging