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Dissociation of Down syndrome and Alzheimer's disease effects with imaging
INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477635/ https://www.ncbi.nlm.nih.gov/pubmed/28642933 http://dx.doi.org/10.1016/j.trci.2016.02.004 |
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author | Matthews, Dawn C. Lukic, Ana S. Andrews, Randolph D. Marendic, Boris Brewer, James Rissman, Robert A. Mosconi, Lisa Strother, Stephen C. Wernick, Miles N. Mobley, William C. Ness, Seth Schmidt, Mark E. Rafii, Michael S. |
author_facet | Matthews, Dawn C. Lukic, Ana S. Andrews, Randolph D. Marendic, Boris Brewer, James Rissman, Robert A. Mosconi, Lisa Strother, Stephen C. Wernick, Miles N. Mobley, William C. Ness, Seth Schmidt, Mark E. Rafii, Michael S. |
author_sort | Matthews, Dawn C. |
collection | PubMed |
description | INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects. METHODS: We evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods. RESULTS: Our results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures. DISCUSSION: These findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults. |
format | Online Article Text |
id | pubmed-5477635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54776352017-06-20 Dissociation of Down syndrome and Alzheimer's disease effects with imaging Matthews, Dawn C. Lukic, Ana S. Andrews, Randolph D. Marendic, Boris Brewer, James Rissman, Robert A. Mosconi, Lisa Strother, Stephen C. Wernick, Miles N. Mobley, William C. Ness, Seth Schmidt, Mark E. Rafii, Michael S. Alzheimers Dement (N Y) Featured Article INTRODUCTION: Down Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of therapeutic intervention, it is necessary to dissociate the contributions of DS and AD from overall phenotype. Imaging biomarkers offer the potential to characterize and stratify patients who will worsen clinically but have yielded mixed findings in DS subjects. METHODS: We evaluated 18F fluorodeoxyglucose positron emission tomography (PET), florbetapir PET, and structural magnetic resonance (sMR) image data from 12 nondemented DS adults using advanced multivariate machine learning methods. RESULTS: Our results showed distinctive patterns of glucose metabolism and brain volume enabling dissociation of DS and AD effects. AD-like pattern expression corresponded to amyloid burden and clinical measures. DISCUSSION: These findings lay groundwork to enable AD clinical trials with characterization and disease-specific tracking of DS adults. Elsevier 2016-03-08 /pmc/articles/PMC5477635/ /pubmed/28642933 http://dx.doi.org/10.1016/j.trci.2016.02.004 Text en © 2016 ADM Diagnostics http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Featured Article Matthews, Dawn C. Lukic, Ana S. Andrews, Randolph D. Marendic, Boris Brewer, James Rissman, Robert A. Mosconi, Lisa Strother, Stephen C. Wernick, Miles N. Mobley, William C. Ness, Seth Schmidt, Mark E. Rafii, Michael S. Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title | Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title_full | Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title_fullStr | Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title_full_unstemmed | Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title_short | Dissociation of Down syndrome and Alzheimer's disease effects with imaging |
title_sort | dissociation of down syndrome and alzheimer's disease effects with imaging |
topic | Featured Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477635/ https://www.ncbi.nlm.nih.gov/pubmed/28642933 http://dx.doi.org/10.1016/j.trci.2016.02.004 |
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