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Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice

The physiologic function of adipose tissue is altered by the host's inflammatory response; the implications for maintaining human health and regulating inflammation-associated disease progression are ill defined. However, this cannot be investigated in humans, therefore the use of animal models...

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Autores principales: Sime, Katie, Choy, Ernest H., Williams, Anwen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477713/
https://www.ncbi.nlm.nih.gov/pubmed/28425846
http://dx.doi.org/10.1080/21623945.2017.1295174
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author Sime, Katie
Choy, Ernest H.
Williams, Anwen S.
author_facet Sime, Katie
Choy, Ernest H.
Williams, Anwen S.
author_sort Sime, Katie
collection PubMed
description The physiologic function of adipose tissue is altered by the host's inflammatory response; the implications for maintaining human health and regulating inflammation-associated disease progression are ill defined. However, this cannot be investigated in humans, therefore the use of animal models is required. With the aim to determine morphological and molecular alterations to perivascular and organ-associated adipose tissues during inflammatory arthritis, collagen-induced arthritis (CIA) was established in male DBA/1 mice. Emerging evidence from this study signposts CIA in the DBA/1 mouse as a model that is relevant to study the development and treatment of early cardiovascular pathology associated with inflammatory arthritis. Here, we show global morphological changes in adipose tissue and the thoracic aorta in animals induced with CIA compared with the non-immunized controls. In CIA, we concluded that the increased cell count in PVAT was, at least in part, caused by an ingress and/or expansion of macrophages that had a mixed phenotype. A substantial increase of galectin-3 was expressed in PVAT from mice with CIA. Galectin-3 is elevated in the blood of patients with CVDs, however, it has never before been measured in PVAT in rodents or humans. Here, PVAT-associated galectin-3 is identified as a potential biomarker for detecting early vascular pathology in CIA and a promising candidate for translation to RA.
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spelling pubmed-54777132017-06-27 Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice Sime, Katie Choy, Ernest H. Williams, Anwen S. Adipocyte Research Paper The physiologic function of adipose tissue is altered by the host's inflammatory response; the implications for maintaining human health and regulating inflammation-associated disease progression are ill defined. However, this cannot be investigated in humans, therefore the use of animal models is required. With the aim to determine morphological and molecular alterations to perivascular and organ-associated adipose tissues during inflammatory arthritis, collagen-induced arthritis (CIA) was established in male DBA/1 mice. Emerging evidence from this study signposts CIA in the DBA/1 mouse as a model that is relevant to study the development and treatment of early cardiovascular pathology associated with inflammatory arthritis. Here, we show global morphological changes in adipose tissue and the thoracic aorta in animals induced with CIA compared with the non-immunized controls. In CIA, we concluded that the increased cell count in PVAT was, at least in part, caused by an ingress and/or expansion of macrophages that had a mixed phenotype. A substantial increase of galectin-3 was expressed in PVAT from mice with CIA. Galectin-3 is elevated in the blood of patients with CVDs, however, it has never before been measured in PVAT in rodents or humans. Here, PVAT-associated galectin-3 is identified as a potential biomarker for detecting early vascular pathology in CIA and a promising candidate for translation to RA. Taylor & Francis 2017-02-21 /pmc/articles/PMC5477713/ /pubmed/28425846 http://dx.doi.org/10.1080/21623945.2017.1295174 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Research Paper
Sime, Katie
Choy, Ernest H.
Williams, Anwen S.
Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title_full Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title_fullStr Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title_full_unstemmed Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title_short Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice
title_sort alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in dba/1 mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477713/
https://www.ncbi.nlm.nih.gov/pubmed/28425846
http://dx.doi.org/10.1080/21623945.2017.1295174
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