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Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte

OBJECTIVE: The objective of this study is to estimate the attrition rates and evaluate factors associated with loss to follow-up between 1994 and 2011 in an open cohort of HIV-negative men who have sex with men. METHODS: The Project Horizonte is an open cohort study that aimed to assess the incidenc...

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Autores principales: Silva, Ana Paula, Greco, Marília, Fausto, Maria Arlene, Carneiro, Mariângela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Saúde Pública da Universidade de São Paulo 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477724/
https://www.ncbi.nlm.nih.gov/pubmed/28678908
http://dx.doi.org/10.1590/S1518-8787.2017051006681
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author Silva, Ana Paula
Greco, Marília
Fausto, Maria Arlene
Carneiro, Mariângela
author_facet Silva, Ana Paula
Greco, Marília
Fausto, Maria Arlene
Carneiro, Mariângela
author_sort Silva, Ana Paula
collection PubMed
description OBJECTIVE: The objective of this study is to estimate the attrition rates and evaluate factors associated with loss to follow-up between 1994 and 2011 in an open cohort of HIV-negative men who have sex with men. METHODS: The Project Horizonte is an open cohort study that aimed to assess the incidence of HIV infection, evaluate the impact of educational interventions, and identify potential volunteers for HIV vaccine trials. The rates of losses to follow-up were estimated for three periods (1994–1999, 2000–2005, and 2006–2011). The variables analyzed were collected in a psychosocial questionnaire. Volunteers who dropped out were compared with the ones who remained in the study using a Cox regression model. RESULTS: A total of 1,197 volunteers were recruited. The median follow-up time in the study (n = 626) was 4.2 years. The median follow-up time for the volunteers who dropped out of the study (n = 571) was 1.46 years. The overall rate of loss to follow-up was 11.6/100 person-years. Attrition rates by period were: 12.60 (1994–1999), 11.80 (2000–2005), and 9.00 (2006–2011) per 100 person-years. Factors associated with losses to follow-up were: age group of 21–30 years old, monthly per capita income of more than six or less than one Brazilian minimum wage, having more than two dependents, report of bisexual practice, and inconsistent use of condoms for receptive anal sex. CONCLUSIONS: A slight decrease of the loss to follow-up was observed over time. Higher attrition rates happened in the first three years of follow-up. It is possible that the link of the volunteers were not yet well established. Those who reported inconsistent condom use in receptive anal sex were more likely to leave the study, suggesting an underestimation of the incidence of HIV infection in a cohort population. For greater effectiveness, retention strategies must be reassessed considering the connection between the characteristics of homosexual and bisexual behavior and the motivations to engage in health research.
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spelling pubmed-54777242017-06-27 Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte Silva, Ana Paula Greco, Marília Fausto, Maria Arlene Carneiro, Mariângela Rev Saude Publica Artigos Originais OBJECTIVE: The objective of this study is to estimate the attrition rates and evaluate factors associated with loss to follow-up between 1994 and 2011 in an open cohort of HIV-negative men who have sex with men. METHODS: The Project Horizonte is an open cohort study that aimed to assess the incidence of HIV infection, evaluate the impact of educational interventions, and identify potential volunteers for HIV vaccine trials. The rates of losses to follow-up were estimated for three periods (1994–1999, 2000–2005, and 2006–2011). The variables analyzed were collected in a psychosocial questionnaire. Volunteers who dropped out were compared with the ones who remained in the study using a Cox regression model. RESULTS: A total of 1,197 volunteers were recruited. The median follow-up time in the study (n = 626) was 4.2 years. The median follow-up time for the volunteers who dropped out of the study (n = 571) was 1.46 years. The overall rate of loss to follow-up was 11.6/100 person-years. Attrition rates by period were: 12.60 (1994–1999), 11.80 (2000–2005), and 9.00 (2006–2011) per 100 person-years. Factors associated with losses to follow-up were: age group of 21–30 years old, monthly per capita income of more than six or less than one Brazilian minimum wage, having more than two dependents, report of bisexual practice, and inconsistent use of condoms for receptive anal sex. CONCLUSIONS: A slight decrease of the loss to follow-up was observed over time. Higher attrition rates happened in the first three years of follow-up. It is possible that the link of the volunteers were not yet well established. Those who reported inconsistent condom use in receptive anal sex were more likely to leave the study, suggesting an underestimation of the incidence of HIV infection in a cohort population. For greater effectiveness, retention strategies must be reassessed considering the connection between the characteristics of homosexual and bisexual behavior and the motivations to engage in health research. Faculdade de Saúde Pública da Universidade de São Paulo 2017-06-20 /pmc/articles/PMC5477724/ /pubmed/28678908 http://dx.doi.org/10.1590/S1518-8787.2017051006681 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Artigos Originais
Silva, Ana Paula
Greco, Marília
Fausto, Maria Arlene
Carneiro, Mariângela
Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title_full Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title_fullStr Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title_full_unstemmed Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title_short Loss to follow-up in a cohort of HIV-negative men who have sex with men: Project Horizonte
title_sort loss to follow-up in a cohort of hiv-negative men who have sex with men: project horizonte
topic Artigos Originais
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477724/
https://www.ncbi.nlm.nih.gov/pubmed/28678908
http://dx.doi.org/10.1590/S1518-8787.2017051006681
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