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Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor

Sexual reproduction brings together reproductive partners whose long‐term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their offspring gain fitness benefits, even if this compromises future reproductive inve...

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Autores principales: Saldivar Lemus, Yolitzi, Vielle‐Calzada, Jean‐Philippe, Ritchie, Michael G., Macías Garcia, Constantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478053/
https://www.ncbi.nlm.nih.gov/pubmed/28649356
http://dx.doi.org/10.1002/ece3.3025
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author Saldivar Lemus, Yolitzi
Vielle‐Calzada, Jean‐Philippe
Ritchie, Michael G.
Macías Garcia, Constantino
author_facet Saldivar Lemus, Yolitzi
Vielle‐Calzada, Jean‐Philippe
Ritchie, Michael G.
Macías Garcia, Constantino
author_sort Saldivar Lemus, Yolitzi
collection PubMed
description Sexual reproduction brings together reproductive partners whose long‐term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their offspring gain fitness benefits, even if this compromises future reproductive investment by iteroparous females. When the conflict occurs at a genomic level, it may be uncovered by crossing divergent populations, as a mismatch in the coevolved patterns of paternal manipulation and maternal resistance may generate asymmetric embryonic growth. We report such an asymmetry in reciprocal crosses between populations of the fish Girardinichthys multiradiatus. We also show that a fragment of a gene which can influence embryonic growth (Insulin‐Like Growth Factor 2; igf2) exhibits a parent‐of‐origin methylation pattern, where the maternally inherited igf2 allele has much more 5′ cytosine methylation than the paternally inherited allele. Our findings suggest that male manipulation of maternal investment may have evolved in fish, while the parent‐of‐origin methylation pattern appears to be a potential candidate mechanism modulating this antagonistic coevolution process. However, disruption of other coadaptive processes cannot be ruled out, as these can lead to similar effects as conflict.
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spelling pubmed-54780532017-06-23 Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor Saldivar Lemus, Yolitzi Vielle‐Calzada, Jean‐Philippe Ritchie, Michael G. Macías Garcia, Constantino Ecol Evol Original Research Sexual reproduction brings together reproductive partners whose long‐term interests often differ, raising the possibility of conflict over their reproductive investment. Males that enhance maternal investment in their offspring gain fitness benefits, even if this compromises future reproductive investment by iteroparous females. When the conflict occurs at a genomic level, it may be uncovered by crossing divergent populations, as a mismatch in the coevolved patterns of paternal manipulation and maternal resistance may generate asymmetric embryonic growth. We report such an asymmetry in reciprocal crosses between populations of the fish Girardinichthys multiradiatus. We also show that a fragment of a gene which can influence embryonic growth (Insulin‐Like Growth Factor 2; igf2) exhibits a parent‐of‐origin methylation pattern, where the maternally inherited igf2 allele has much more 5′ cytosine methylation than the paternally inherited allele. Our findings suggest that male manipulation of maternal investment may have evolved in fish, while the parent‐of‐origin methylation pattern appears to be a potential candidate mechanism modulating this antagonistic coevolution process. However, disruption of other coadaptive processes cannot be ruled out, as these can lead to similar effects as conflict. John Wiley and Sons Inc. 2017-05-15 /pmc/articles/PMC5478053/ /pubmed/28649356 http://dx.doi.org/10.1002/ece3.3025 Text en © 2017 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Saldivar Lemus, Yolitzi
Vielle‐Calzada, Jean‐Philippe
Ritchie, Michael G.
Macías Garcia, Constantino
Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title_full Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title_fullStr Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title_full_unstemmed Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title_short Asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
title_sort asymmetric paternal effect on offspring size linked to parent‐of‐origin expression of an insulin‐like growth factor
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478053/
https://www.ncbi.nlm.nih.gov/pubmed/28649356
http://dx.doi.org/10.1002/ece3.3025
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