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In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles

AIMS: Short QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, I(Kr)) of SQTS, results from an inactivation-at...

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Detalles Bibliográficos
Autores principales:	Luo, Cunjin, Wang, Kuanquan, Zhang, Henggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478111/ https://www.ncbi.nlm.nih.gov/pubmed/28632743 http://dx.doi.org/10.1371/journal.pone.0179515

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