Cargando…
Metformin intake associates with better cognitive function in patients with Huntington's disease
Huntington’s disease (HD) is an inherited, dominant neurodegenerative disorder caused by an abnormal expansion of CAG triplets in the huntingtin gene (htt). Despite extensive efforts to modify the progression of HD thus far only symptomatic treatment is available. Recent work suggests that treating...
Autores principales: | Hervás, David, Fornés-Ferrer, Victoria, Gómez-Escribano, Ana Pilar, Sequedo, María Dolores, Peiró, Carmen, Millán, José María, Vázquez-Manrique, Rafael P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478119/ https://www.ncbi.nlm.nih.gov/pubmed/28632780 http://dx.doi.org/10.1371/journal.pone.0179283 |
Ejemplares similares
-
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019) -
Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?
por: Bono-Yagüe, José, et al.
Publicado: (2020) -
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans
por: Gómez-Escribano, AP, et al.
Publicado: (2020) -
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease
por: Vázquez-Manrique, Rafael P., et al.
Publicado: (2016) -
Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease
por: Merino, Marián, et al.
Publicado: (2022)