Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has...

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Detalles Bibliográficos
Autores principales: Steinman, Jonathan B, Santarossa, Cristina C, Miller, Rand M, Yu, Lola S, Serpinskaya, Anna S, Furukawa, Hideki, Morimoto, Sachie, Tanaka, Yuta, Nishitani, Mitsuyoshi, Asano, Moriteru, Zalyte, Ruta, Ondrus, Alison E, Johnson, Alex G, Ye, Fan, Nachury, Maxence V, Fukase, Yoshiyuki, Aso, Kazuyoshi, Foley, Michael A, Gelfand, Vladimir I, Chen, James K, Carter, Andrew P, Kapoor, Tarun M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478271/
https://www.ncbi.nlm.nih.gov/pubmed/28524820
http://dx.doi.org/10.7554/eLife.25174

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