Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient

A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic varia...

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Autores principales: D Hayashi, Reiko, Yamaoka, Masaya, Nishizawa, Hitoshi, Fukuda, Shiro, Fujishima, Yuya, Kimura, Takekazu, Kozawa, Jyunji, Kita, Shunbun, Matsuoka, Taka-aki, Otsuki, Michio, Imagawa, Akihisa, Ichida, Kimiyoshi, Taniguchi, Atsuo, Maeda, Norikazu, Funahashi, Tohru, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478570/
https://www.ncbi.nlm.nih.gov/pubmed/28458315
http://dx.doi.org/10.2169/internalmedicine.56.7923
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author D Hayashi, Reiko
Yamaoka, Masaya
Nishizawa, Hitoshi
Fukuda, Shiro
Fujishima, Yuya
Kimura, Takekazu
Kozawa, Jyunji
Kita, Shunbun
Matsuoka, Taka-aki
Otsuki, Michio
Imagawa, Akihisa
Ichida, Kimiyoshi
Taniguchi, Atsuo
Maeda, Norikazu
Funahashi, Tohru
Shimomura, Iichiro
author_facet D Hayashi, Reiko
Yamaoka, Masaya
Nishizawa, Hitoshi
Fukuda, Shiro
Fujishima, Yuya
Kimura, Takekazu
Kozawa, Jyunji
Kita, Shunbun
Matsuoka, Taka-aki
Otsuki, Michio
Imagawa, Akihisa
Ichida, Kimiyoshi
Taniguchi, Atsuo
Maeda, Norikazu
Funahashi, Tohru
Shimomura, Iichiro
author_sort D Hayashi, Reiko
collection PubMed
description A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient’s pro-inflammatory cytokine (IL-1β) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi.
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spelling pubmed-54785702017-06-21 Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient D Hayashi, Reiko Yamaoka, Masaya Nishizawa, Hitoshi Fukuda, Shiro Fujishima, Yuya Kimura, Takekazu Kozawa, Jyunji Kita, Shunbun Matsuoka, Taka-aki Otsuki, Michio Imagawa, Akihisa Ichida, Kimiyoshi Taniguchi, Atsuo Maeda, Norikazu Funahashi, Tohru Shimomura, Iichiro Intern Med Case Report A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient’s pro-inflammatory cytokine (IL-1β) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi. The Japanese Society of Internal Medicine 2017-05-01 /pmc/articles/PMC5478570/ /pubmed/28458315 http://dx.doi.org/10.2169/internalmedicine.56.7923 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
D Hayashi, Reiko
Yamaoka, Masaya
Nishizawa, Hitoshi
Fukuda, Shiro
Fujishima, Yuya
Kimura, Takekazu
Kozawa, Jyunji
Kita, Shunbun
Matsuoka, Taka-aki
Otsuki, Michio
Imagawa, Akihisa
Ichida, Kimiyoshi
Taniguchi, Atsuo
Maeda, Norikazu
Funahashi, Tohru
Shimomura, Iichiro
Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title_full Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title_fullStr Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title_full_unstemmed Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title_short Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient
title_sort multiple gouty tophi with bone erosion and destruction: a report of an early-onset case in an obese patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478570/
https://www.ncbi.nlm.nih.gov/pubmed/28458315
http://dx.doi.org/10.2169/internalmedicine.56.7923
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