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Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions

A 59-year-old man presented with multiple dark red erythemas with induration, anemia, and polyclonal hypergammaglobulinemia. A skin biopsy revealed the infiltration of lymphocytes and plasma cells and he was initially diagnosed with multicentric Castleman's disease (MCD). Glucocorticoid treatme...

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Autores principales: Mochizuki, Hiroki, Kato, Manako, Higuchi, Takakazu, Koyamada, Ryosuke, Arai, Satoru, Okada, Sadamu, Eto, Hikaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478574/
https://www.ncbi.nlm.nih.gov/pubmed/28458319
http://dx.doi.org/10.2169/internalmedicine.56.8013
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author Mochizuki, Hiroki
Kato, Manako
Higuchi, Takakazu
Koyamada, Ryosuke
Arai, Satoru
Okada, Sadamu
Eto, Hikaru
author_facet Mochizuki, Hiroki
Kato, Manako
Higuchi, Takakazu
Koyamada, Ryosuke
Arai, Satoru
Okada, Sadamu
Eto, Hikaru
author_sort Mochizuki, Hiroki
collection PubMed
description A 59-year-old man presented with multiple dark red erythemas with induration, anemia, and polyclonal hypergammaglobulinemia. A skin biopsy revealed the infiltration of lymphocytes and plasma cells and he was initially diagnosed with multicentric Castleman's disease (MCD). Glucocorticoid treatment was only partially effective. Four years later, the patient's bilateral lacrimal glands gradually became enlarged and a biopsy revealed dense lymphocyte and plasma cell infiltration with an IgG4+/IgG+ plasma cell ratio of 70%. The patient was diagnosed with IgG4-related disease (RD). Rituximab only had a slight effect. This case demonstrates that overlapping features of IgG4-RD and MCD may present in a single patient, which suggests a shared pathogenesis.
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spelling pubmed-54785742017-06-21 Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions Mochizuki, Hiroki Kato, Manako Higuchi, Takakazu Koyamada, Ryosuke Arai, Satoru Okada, Sadamu Eto, Hikaru Intern Med Case Report A 59-year-old man presented with multiple dark red erythemas with induration, anemia, and polyclonal hypergammaglobulinemia. A skin biopsy revealed the infiltration of lymphocytes and plasma cells and he was initially diagnosed with multicentric Castleman's disease (MCD). Glucocorticoid treatment was only partially effective. Four years later, the patient's bilateral lacrimal glands gradually became enlarged and a biopsy revealed dense lymphocyte and plasma cell infiltration with an IgG4+/IgG+ plasma cell ratio of 70%. The patient was diagnosed with IgG4-related disease (RD). Rituximab only had a slight effect. This case demonstrates that overlapping features of IgG4-RD and MCD may present in a single patient, which suggests a shared pathogenesis. The Japanese Society of Internal Medicine 2017-05-01 /pmc/articles/PMC5478574/ /pubmed/28458319 http://dx.doi.org/10.2169/internalmedicine.56.8013 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mochizuki, Hiroki
Kato, Manako
Higuchi, Takakazu
Koyamada, Ryosuke
Arai, Satoru
Okada, Sadamu
Eto, Hikaru
Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title_full Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title_fullStr Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title_full_unstemmed Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title_short Overlap of IgG4-related Disease and Multicentric Castleman's Disease in a Patient with Skin Lesions
title_sort overlap of igg4-related disease and multicentric castleman's disease in a patient with skin lesions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478574/
https://www.ncbi.nlm.nih.gov/pubmed/28458319
http://dx.doi.org/10.2169/internalmedicine.56.8013
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