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Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer

Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation comp...

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Detalles Bibliográficos
Autores principales:	Kiehl, Steffen, Zimmermann, Tobias, Savai, Rajkumar, Pullamsetti, Soni S., Seeger, Werner, Bartkuhn, Marek, Dammann, Reinhard H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478622/ https://www.ncbi.nlm.nih.gov/pubmed/28634396 http://dx.doi.org/10.1038/s41598-017-04248-w

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