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A central mechanism enhances pain perception of noxious thermal stimulus changes

Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism in the ce...

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Autores principales: Petre, B., Tetreault, P., Mathur, V. A., Schurgin, M. W., Chiao, J. Y., Huang, L., Apkarian, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478630/
https://www.ncbi.nlm.nih.gov/pubmed/28634321
http://dx.doi.org/10.1038/s41598-017-04009-9
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author Petre, B.
Tetreault, P.
Mathur, V. A.
Schurgin, M. W.
Chiao, J. Y.
Huang, L.
Apkarian, A. V.
author_facet Petre, B.
Tetreault, P.
Mathur, V. A.
Schurgin, M. W.
Chiao, J. Y.
Huang, L.
Apkarian, A. V.
author_sort Petre, B.
collection PubMed
description Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism in the central nervous system underlies thermal TCE. Our model successfully predicted an optimal stimulus, incorporating a transient temperature offset (step-up/step-down), with maximal TCE, resulting in psychophysically verified large decrements in pain response (“offset-analgesia”; mean analgesia: 85%, n = 20 subjects). Next, this stimulus was delivered using two thermodes, one delivering the longer duration baseline temperature pulse and the other superimposing a short higher temperature pulse. The two stimuli were applied simultaneously either near or far on the same arm, or on opposite arms. Spatial separation across multiple peripheral receptive fields ensures the composite stimulus timecourse is first reconstituted in the central nervous system. Following ipsilateral stimulus cessation on the high temperature thermode, but before cessation of the low temperature stimulus properties of TCE were observed both for individual subjects and in group-mean responses. This demonstrates a central integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming transient afferent nociceptive signals into a stable pain perception.
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spelling pubmed-54786302017-06-23 A central mechanism enhances pain perception of noxious thermal stimulus changes Petre, B. Tetreault, P. Mathur, V. A. Schurgin, M. W. Chiao, J. Y. Huang, L. Apkarian, A. V. Sci Rep Article Pain perception temporarily exaggerates abrupt thermal stimulus changes revealing a mechanism for nociceptive temporal contrast enhancement (TCE). Although the mechanism is unknown, a non-linear model with perceptual feedback accurately simulates the phenomenon. Here we test if a mechanism in the central nervous system underlies thermal TCE. Our model successfully predicted an optimal stimulus, incorporating a transient temperature offset (step-up/step-down), with maximal TCE, resulting in psychophysically verified large decrements in pain response (“offset-analgesia”; mean analgesia: 85%, n = 20 subjects). Next, this stimulus was delivered using two thermodes, one delivering the longer duration baseline temperature pulse and the other superimposing a short higher temperature pulse. The two stimuli were applied simultaneously either near or far on the same arm, or on opposite arms. Spatial separation across multiple peripheral receptive fields ensures the composite stimulus timecourse is first reconstituted in the central nervous system. Following ipsilateral stimulus cessation on the high temperature thermode, but before cessation of the low temperature stimulus properties of TCE were observed both for individual subjects and in group-mean responses. This demonstrates a central integration mechanism is sufficient to evoke painful thermal TCE, an essential step in transforming transient afferent nociceptive signals into a stable pain perception. Nature Publishing Group UK 2017-06-20 /pmc/articles/PMC5478630/ /pubmed/28634321 http://dx.doi.org/10.1038/s41598-017-04009-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Petre, B.
Tetreault, P.
Mathur, V. A.
Schurgin, M. W.
Chiao, J. Y.
Huang, L.
Apkarian, A. V.
A central mechanism enhances pain perception of noxious thermal stimulus changes
title A central mechanism enhances pain perception of noxious thermal stimulus changes
title_full A central mechanism enhances pain perception of noxious thermal stimulus changes
title_fullStr A central mechanism enhances pain perception of noxious thermal stimulus changes
title_full_unstemmed A central mechanism enhances pain perception of noxious thermal stimulus changes
title_short A central mechanism enhances pain perception of noxious thermal stimulus changes
title_sort central mechanism enhances pain perception of noxious thermal stimulus changes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478630/
https://www.ncbi.nlm.nih.gov/pubmed/28634321
http://dx.doi.org/10.1038/s41598-017-04009-9
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