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The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known...

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Autores principales: Jiang, Zhou, Qian, Jun, Dong, Haiyan, Yang, Jingyi, Yu, Xiaobo, Chen, Jianzhong, Chen, Hongning, Shi, Qing, Jia, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478643/
https://www.ncbi.nlm.nih.gov/pubmed/28634392
http://dx.doi.org/10.1038/s41598-017-02054-y
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author Jiang, Zhou
Qian, Jun
Dong, Haiyan
Yang, Jingyi
Yu, Xiaobo
Chen, Jianzhong
Chen, Hongning
Shi, Qing
Jia, Lee
author_facet Jiang, Zhou
Qian, Jun
Dong, Haiyan
Yang, Jingyi
Yu, Xiaobo
Chen, Jianzhong
Chen, Hongning
Shi, Qing
Jia, Lee
author_sort Jiang, Zhou
collection PubMed
description Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known abortion herb Achyranthes bidentata Blume (A. bidentata). Five compounds were separated from the herb root. Among them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentrations. It specifically inhibited the metastatic dissemination capability of colon cancer cells HT29, including the migration and invasion ability, and their adhesion to human endothelium through inhibiting integrin αvβ6, MMP-2, MMP-9, and ERK phosphorylation by HT29. Pretreatment of nude mice with oral ginsenoside Ro followed by HT29 intravenous inoculation and 40-day oral ginsenoside Ro significantly prevented lung metastasis with downregulation of integrin αvβ6 and no toxicity. The present study firstly introduces the new conception of utilizing safe and effective abortion botanic medicines for CTC-based metastatic chemoprevention.
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spelling pubmed-54786432017-06-23 The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology Jiang, Zhou Qian, Jun Dong, Haiyan Yang, Jingyi Yu, Xiaobo Chen, Jianzhong Chen, Hongning Shi, Qing Jia, Lee Sci Rep Article Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known abortion herb Achyranthes bidentata Blume (A. bidentata). Five compounds were separated from the herb root. Among them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentrations. It specifically inhibited the metastatic dissemination capability of colon cancer cells HT29, including the migration and invasion ability, and their adhesion to human endothelium through inhibiting integrin αvβ6, MMP-2, MMP-9, and ERK phosphorylation by HT29. Pretreatment of nude mice with oral ginsenoside Ro followed by HT29 intravenous inoculation and 40-day oral ginsenoside Ro significantly prevented lung metastasis with downregulation of integrin αvβ6 and no toxicity. The present study firstly introduces the new conception of utilizing safe and effective abortion botanic medicines for CTC-based metastatic chemoprevention. Nature Publishing Group UK 2017-06-20 /pmc/articles/PMC5478643/ /pubmed/28634392 http://dx.doi.org/10.1038/s41598-017-02054-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jiang, Zhou
Qian, Jun
Dong, Haiyan
Yang, Jingyi
Yu, Xiaobo
Chen, Jianzhong
Chen, Hongning
Shi, Qing
Jia, Lee
The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title_full The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title_fullStr The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title_full_unstemmed The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title_short The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
title_sort traditional chinese medicine achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478643/
https://www.ncbi.nlm.nih.gov/pubmed/28634392
http://dx.doi.org/10.1038/s41598-017-02054-y
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