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Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding tha...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478645/ https://www.ncbi.nlm.nih.gov/pubmed/28634337 http://dx.doi.org/10.1038/s41598-017-04145-2 |
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author | Alexandersen, Soren Nelson, Tiffanie M. Hodge, Jason Druce, Julian |
author_facet | Alexandersen, Soren Nelson, Tiffanie M. Hodge, Jason Druce, Julian |
author_sort | Alexandersen, Soren |
collection | PubMed |
description | We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015. |
format | Online Article Text |
id | pubmed-5478645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54786452017-06-23 Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 Alexandersen, Soren Nelson, Tiffanie M. Hodge, Jason Druce, Julian Sci Rep Article We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015. Nature Publishing Group UK 2017-06-20 /pmc/articles/PMC5478645/ /pubmed/28634337 http://dx.doi.org/10.1038/s41598-017-04145-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Alexandersen, Soren Nelson, Tiffanie M. Hodge, Jason Druce, Julian Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title | Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title_full | Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title_fullStr | Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title_full_unstemmed | Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title_short | Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3 |
title_sort | evolutionary and network analysis of virus sequences from infants infected with an australian recombinant strain of human parechovirus type 3 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478645/ https://www.ncbi.nlm.nih.gov/pubmed/28634337 http://dx.doi.org/10.1038/s41598-017-04145-2 |
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