Topical Fibronectin Improves Wound Healing of Irradiated Skin

Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, f...

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Detalles Bibliográficos
Autores principales: Johnson, Maxwell B., Pang, Brandon, Gardner, Daniel J., Niknam-Benia, Solmaz, Soundarajan, Vinaya, Bramos, Athanasios, Perrault, David P., Banks, Kian, Lee, Gene K., Baker, Regina Y., Kim, Gene H., Lee, Sunju, Chai, Yang, Chen, Mei, Li, Wei, Kwong, Lawrence, Hong, Young-Kwon, Wong, Alex K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478660/
https://www.ncbi.nlm.nih.gov/pubmed/28634413
http://dx.doi.org/10.1038/s41598-017-03614-y
Descripción
Sumario:Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.

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