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Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo

Increasing evidence indicates that Nrf-2, named the nuclear factor-erythroid 2-related factor, may perform anticancer function. In this study, a series of novel substituted phenyl- (3-methyl-1H-indol-2-yl)-prop-2-en-1-one (indolyl-chalcone) derivatives were synthesized and their effects on Nrf-2 act...

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Detalles Bibliográficos
Autores principales:	Zhao, Xuan, Dong, WenLiang, Gao, YuanDi, Shin, Dong-Shoo, Ye, Qing, Su, Le, Jiang, Fan, Zhao, BaoXiang, Miao, JunYing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478673/ https://www.ncbi.nlm.nih.gov/pubmed/28634389 http://dx.doi.org/10.1038/s41598-017-04411-3

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