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NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

BACKGROUND/AIMS: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine. The strong associations identified between NUDT15 p.Arg139Cys and thiopurine-induced leukopenia and severe hair loss have b...

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Detalles Bibliográficos
Autores principales:	Sato, Toshiyuki, Takagawa, Tetsuya, Kakuta, Yoichi, Nishio, Akihiro, Kawai, Mikio, Kamikozuru, Koji, Yokoyama, Yoko, Kita, Yuko, Miyazaki, Takako, Iimuro, Masaki, Hida, Nobuyuki, Hori, Kazutoshi, Ikeuchi, Hiroki, Nakamura, Shiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Association for the Study of Intestinal Diseases 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478757/ https://www.ncbi.nlm.nih.gov/pubmed/28670229 http://dx.doi.org/10.5217/ir.2017.15.3.328

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