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Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations

Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establis...

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Autores principales: Riezzo, Irene, Pascale, Natascha, La Russa, Raffaele, Liso, Arcangelo, Salerno, Monica, Turillazzi, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478865/
https://www.ncbi.nlm.nih.gov/pubmed/28680446
http://dx.doi.org/10.1155/2017/5250790
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author Riezzo, Irene
Pascale, Natascha
La Russa, Raffaele
Liso, Arcangelo
Salerno, Monica
Turillazzi, Emanuela
author_facet Riezzo, Irene
Pascale, Natascha
La Russa, Raffaele
Liso, Arcangelo
Salerno, Monica
Turillazzi, Emanuela
author_sort Riezzo, Irene
collection PubMed
description Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. HSCT imposes operative cautions so that the entire donation/transplantation procedure is safe for both donors and recipients; it carries with it significant clinical, moral, and ethical concerns, mostly when donors are minors. The following points have been stressed: the donation should be excluded when excessive risks for the donor are reasonable, donors must receive an accurate information regarding eventual adverse events and health burden for the donors themselves, a valid consent is required, and the recipient's risks must be outweighed by the expected benefits. The issue of conflict of interest, when the same physician has the responsibility for both donor selection and recipient care, is highlighted as well as the need of an adequate insurance protection for all the parties involved.
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spelling pubmed-54788652017-07-05 Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations Riezzo, Irene Pascale, Natascha La Russa, Raffaele Liso, Arcangelo Salerno, Monica Turillazzi, Emanuela Stem Cells Int Review Article Allogenic hematopoietic progenitor cell transplantation (allo-HSCT) is an established treatment for many diseases. Stem cells may be obtained from different sources: mobilized peripheral blood stem cells, bone marrow, and umbilical cord blood. The progress in transplantation procedures, the establishment of experienced transplant centres, and the creation of unrelated adult donor registries and cord blood banks gave those without an human leucocyte antigen- (HLA-) identical sibling donor the opportunity to find a donor and cord blood units worldwide. HSCT imposes operative cautions so that the entire donation/transplantation procedure is safe for both donors and recipients; it carries with it significant clinical, moral, and ethical concerns, mostly when donors are minors. The following points have been stressed: the donation should be excluded when excessive risks for the donor are reasonable, donors must receive an accurate information regarding eventual adverse events and health burden for the donors themselves, a valid consent is required, and the recipient's risks must be outweighed by the expected benefits. The issue of conflict of interest, when the same physician has the responsibility for both donor selection and recipient care, is highlighted as well as the need of an adequate insurance protection for all the parties involved. Hindawi 2017 2017-06-07 /pmc/articles/PMC5478865/ /pubmed/28680446 http://dx.doi.org/10.1155/2017/5250790 Text en Copyright © 2017 Irene Riezzo et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Riezzo, Irene
Pascale, Natascha
La Russa, Raffaele
Liso, Arcangelo
Salerno, Monica
Turillazzi, Emanuela
Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title_full Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title_fullStr Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title_full_unstemmed Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title_short Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
title_sort donor selection for allogenic hemopoietic stem cell transplantation: clinical and ethical considerations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478865/
https://www.ncbi.nlm.nih.gov/pubmed/28680446
http://dx.doi.org/10.1155/2017/5250790
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