Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a ch...

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Detalles Bibliográficos
Autores principales: Munro, Shonagh, Hookway, Edward S., Floderer, Melanie, Carr, Simon M., Konietzny, Rebecca, Kessler, Benedikt M., Oppermann, Udo, La Thangue, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478878/
https://www.ncbi.nlm.nih.gov/pubmed/28614707
http://dx.doi.org/10.1016/j.celrep.2017.05.053

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